Results 101 to 110 of about 1,389,981 (273)

Designing multifunctional chemical sensors using Ni and Cu doped carbon nanotubes [PDF]

, 2010
We demonstrate a "bottom up" approach to the computational design of a multifunctional chemical sensor. General techniques are employed for describing the adsorption coverage and resistance properties of the sensor based on density functional theory (DFT)
Arnold, Ayala, Brahim, Chalier, Chan, Collins, De Blauwe, Fagan, Fagan, Fürst, Garca-Lastra, García-Lastra, Hierold, Jensen, Klie, Kong, Kramberger, Krasheninnikov, Lassagne, Li, Lide, Morgan, Mortensen, Mowbray, Perdew, Rocha, Soler, Strange, Suenaga, Tu, Villalpando-Páez, Vo, Yagi, Yang, Yeung, Zheng, Zheng   +36 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage [PDF]

, 2008
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood.
Binaschi, Borgnetto, Brown, Cambau, Champoux, Corbett, Corbett, Ferrero, Fisher, Gatto, Higgins, Kawada, L. M. Fisher, M. Dias, M. Palumbo, Marians, Maxam, McCullough, Mizuuchi, Morrison, Pan, Pan, Pan, Pan, Pan, Peden, Pozzi, Richter, Richter, Richter, Shea, X. S. Pan, Yague, Yoshida, Zechiedrich   +34 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Detection of accase target-site resistant Alopecurus myosuroides huds (black-grass) in Belgian populations [PDF]

, 2009
Black-grass is a common grass weed, widely spread in Northern Europe and also in Belgium. For ages, it has been an increasing problem in industrial crops, especially winter cereals.
Bodson, Bernard, Henriet, François, Maréchal, Pierre-Yves   +2 more
core  

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I [PDF]

, 2012
Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity.
Badura, Susanne, Khateb, Mamduh, Mahajna, Jamal, Metodieva, Anna, Mian, Afsar Ali, Najajreh, Yousef, Ottmann, Oliver Gerhard, Ruimi, Nili, Ruthardt, Martin   +8 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Seasonal variation in species composition and frequency of insecticide resistance alleles (kdr and ace-1r) in the Anopheles gambiae complex from an irrigated rice fields area in Western Burkina Faso [PDF]

, 2009
Monitoring of the spread of insecticide resistance in field vector populations is a prerequisite for the implementation of efficient and sustainable vector control strategies based on the use of insecticides. Screening for resistance alleles in Anopheles
Baldet, Thierry, Dabiré, K.R., Diabaté, Abdoulaye, Namountougou, Moussa, Ouédraogo, Jean-Bosco, Sawadogo, P., Simard, Frédéric, Toé, K.H.   +7 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source