Results 51 to 60 of about 756,924 (286)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV-1 maturation inhibitor bevirimat [PDF]
, 2010 Background: The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-
Sakalian Michael +11 more
core +1 more source
Is hormesis an underestimated factor in the development of herbicide resistance?
Julius-Kühn-Archiv, 2014 The growing impact of herbicide resistant weeds increasingly affects weed management and the delay of resistance evolution has become a major task of chemical weed control.
Belz, Regina G.
doaj +1 more source
Entwicklung der Herbizidresistenz bei Acker-Fuchsschwanz (Alopecurus myosuroides) in Bayern
Julius-Kühn-Archiv, 2020 Acker-Fuchsschwanz (Alopecurus myosuroides) ist eines der wichtigsten Leitungräser im bayerischen Ackerbau. Für die Vermeidung von hohen Ertrags- und Qualitätsverlusten ist eine effektive chemische Bekämpfung in wichtigen Ackerbaukulturen wie ...
Gehring, Klaus +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Fitness costs associated with evolved herbicide resistance alleles in plants [PDF]
, 2009 Predictions based on evolutionary theory suggest that the adaptive value of evolved herbicide resistance alleles may be compromised by the existence of fitness costs.
Martin M. Vila‐Aiub +5 more
core +1 more source
Agronomy, 2020 Corn poppy (Papaver rhoeas L.) and cornflower (Centaurea cyanus L.) are two overwintering weed species found in crop fields in Europe. They are characterised by a similar life cycle, similar competitive efforts, and a spectrum of herbicides recommended ...
Marta Stankiewicz-Kosyl +11 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling
, 2008 Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes.
Field, L.M. +14 more
core +1 more source
Insecticide resistance resulting from an absence of target-site gene product [PDF]
Proceedings of the National Academy of Sciences, 1998 Genetic changes in insects that lead to insecticide resistance include point mutations and up-regulation/amplification of detoxification genes. Here, we report a third mechanism, resistance caused by an absence of gene product. Mutations of the Methoprene-tolerant ( Met ) gene of ...
T G, Wilson, M, Ashok
openaire +2 more sources