Results 81 to 90 of about 1,389,981 (273)

Emergence of knock-down resistance in the Anopheles gambiae complex in the Upper River Region, The Gambia, and its relationship with malaria infection in children

Malaria Journal, 2018
Background Insecticide resistance threatens malaria control in sub-Saharan Africa. Knockdown resistance to pyrethroids and organochlorines in Anopheles gambiae sensu lato (s.l.) is commonly caused by mutations in the gene encoding a voltage-gated sodium ...
Anne L. Wilson, Margaret Pinder, John Bradley, Martin J. Donnelly, Majidah Hamid-Adiamoh, Lamin B. S. Jarju, Musa Jawara, David Jeffries, Ballah Kandeh, Emily J. Rippon, Kolawole Salami, Umberto D’Alessandro, Steven W. Lindsay   +12 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Galium spurium and G. aparine Resistance to ALS-Inhibiting Herbicides in Northern Greece [PDF]

Planta Daninha, 2019
: Knowledge of the level of resistance of weed populations and the herbicides to which they survive is important for recommending suitable advice to farmers and allowing the selection of appropriate management strategies.
A.P. PAPAPANAGIOTOU, C.A. DAMALAS, I. BOSMALI, P. MADESIS, G.C. MENEXES, I.G. ELEFTHEROHORINOS   +5 more
doaj   +1 more source

Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. [PDF]

, 2007
Linezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram-positive pathogens. Clinical resistance to linezolid, so far, has been developing only slowly and has involved exclusively target
Arias, Cesar A, Lolans, Karen, Mankin, Alexander S, Quinn, John, Toh, Seok-Ming, Villegas, Maria V, Xiong, Liqun   +6 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Insight into the herbicide resistance patterns in Lolium rigidum populations in Tunisian and Moroccan wheat regions

Frontiers in Plant Science
Rigid ryegrass (Lolium rigidum Gaud.) is one of the most troublesome weeds in Moroccan and Tunisian cereal crop fields. In total, 19 rigid ryegrass field populations were randomly selected in northern wheat crop areas of Morocco and Tunisia to examine ...
Zakia El-Mastouri, Pavlína Košnarová, Kateřina Hamouzová, Ezzedine Alimi, Josef Soukup   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.

PLoS Genetics, 2021
CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations in the laboratory.
Silke Fuchs, William T Garrood, Anna Beber, Andrew Hammond, Roberto Galizi, Matthew Gribble, Giulia Morselli, Tin-Yu J Hui, Katie Willis, Nace Kranjc, Austin Burt, Andrea Crisanti, Tony Nolan   +12 more
doaj   +1 more source

Glyphosate resistance in annual ryegrass (Lolium rigidum Gaud.) with multiple resistance mechanisms. [PDF]

, 2010
Glyphosate (N-(phosphonomethyl)glycine) is a post-emergent, systemic and non-selective herbicide for the control of annual and perennial weeds. This herbicide has very low toxicity to the mammals.
Bostamam, Yazid
core   +1 more source

Examining the role of protein structural dynamics in drug resistance in Mycobacterium tuberculosis [PDF]

, 2017
Antimicrobial resistance represents a growing global health problem. The emergence of novel resistance mechanisms necessitates the development of alternative approaches to investigate the molecular fundamentals of resistance, leading ultimately to new ...
Adamczyk, Adamczyk, Baiz, Bandaria, Bastian, Best, Chollet, Darden, Deflores, Demirdoven, Dunkelberger, Ganim, Greetham, Hahn, Hamm, Hamm, Hartkoorn, Hess, Hess, Hess, Hochstrasser, Hunt, Husseini, Jansen, Jo, Jorgensen, Kruh, Larsen, Li, Luckner, Merget, Oliveira, Parikh, Perryman, Pronk, Quemard, Rawat, Rozwarski, Shaw, Shaw, Shim, Simpson, Thielges, Torii, Vanommeslaeghe, Verlet, Veyron-Churlet, Veyron-Churlet, Vilcheze, WHO, Zoete   +50 more
core   +2 more sources