Results 41 to 50 of about 62,053 (298)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Firm characteristics, corporate governance and capital structure adjustments: A comparative study of listed firms in Sri Lanka and India

open access: yesIIMB Management Review, 2017
This study explores the most important determinants of speed of adjustment (SOA) towards optimum/target capital structure of listed firms in Sri Lanka and India for the period 2003/04 to 2012/13.
S. Buvanendra   +2 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Ownership and Determinants Capital Structure of Public Listed Companies in Indonesia: a Panel Data Analysis

open access: yesInternational Research Journal of Business Studies, 2013
Capital structure is a mix of debts and equities used by a company to finance its investment. Debt offers benefit of tax shield from interest expenses that can be deducted in calculating company income tax.
Arief Tri Hardiyanto   +3 more
doaj   +3 more sources

The Effect of Firm Financial Position and Industry Characteristics on Capital Structure Adjustment [PDF]

open access: yesJournal of Asset Management and Financing, 2018
This study investigates the influence of deficit and surplus and then the effect of industry characteristics, including industry concentration, industry munificence and industry dynamism on the capital structure adjustment.
Bahareh Haghighi Talab   +2 more
doaj   +1 more source

Capital Structure and Macroeconomic Conditions: Evidence from Canada

open access: yes, 2022
This paper examines the impact of macroeconomic conditions on the capital structure adjustment speed. Using a sample of Canadian firms listed on the Toronto Stock Exchange between 1981 and 2020, I document that firms adjust their capital structure to the
Xu, Xiaoxi
core  

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi   +19 more
wiley   +1 more source

Optimal capital structure of Vietnamese listed firms - finance industry and consumer discretionary industry

open access: yesCogent Social Sciences, 2023
This study makes effort in considering the static structural models with the endogenous bankruptcy boundary in order to maximize the firm’s value. This research starts with highly recognized theoretical frameworks on the capital structure including ...
Thi Thanh Binh Dao, Thu Ha Le
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

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