Results 171 to 180 of about 2,545,393 (299)

DEVELOPMENT OF A COMPLEX TARGET PROGRAM TO IMPROVE LABOR PRODUCTIVITY IN THE LENINGRAD REGION

Economics and management. Research. Innovation Practice, 2019
openaire   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Targeted Interference with USF2 Binding to the SERPINE1 Proximal Promoter E-Box in Dual Mutant p53^R282Q,H179Y Human Keratinocytes Inhibits Serum-/TGF-β1-Induced SERPINE1 Expression and Stimulates Epithelial Cell Proliferation. [PDF]

Biomedicines
Higgins SP, Czekay RP, Higgins CE, Higgins PJ.   +3 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells. [PDF]

Nucleic Acids Res
Feng H, Li Z, Zhang H, Zheng Y, Xu B, Zhang Y, Zou L, Wu L.   +7 more
europepmc   +1 more source

Improving of distribution system and control of assets of regional target program «Development of agricultural complex of Nizhny Novgorod region 2013-2020»

Вестник НГИЭИ, 2014
The article describes the existing distribution system and control of the regional target program «Development of agriculture in Nizhny Novgorod region for 2013-2020», proposes measures to improve the system.
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Back to the future 2: the implications of germplasm structure on the balance between short- and long-term genetic gain in a changing target population of environments. [PDF]

G3 (Bethesda)
Technow F, Podlich D, Cooper M.
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Effectiveness of Program Aid in Pakistan: A Triangular Conceptual Modeling Approach

Lahore Journal of Economics
Foreign aid has been an essential source of external financing for developing countries, with the belief that it can foster growth in recipient nations. Specifically, the type of aid known as Program Aid is particularly important because it provides the
Muhammad Arshad, Sana Hameed Pasha, Naeem Akram   +2 more
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