Results 181 to 190 of about 2,545,393 (299)

A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory. [PDF]

Proc Natl Acad Sci U S A
Koike J, Nakae K, Hira R, Yada Y, Naoki H.   +4 more
europepmc   +1 more source

Program-target planning and management the creation of complex technical and human-machine systems

Radioelectronics. Nanosystems. Information Technologies., 2014
openaire   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

The Histone-Lysine N-Methyltransferase (KMT2) Family in Health and Disease. [PDF]

MedComm (2020)
Wang Q, Bo Z, Zhang Y, Chen Y, Wang Z, Tong S, Xu A, Zhang J, Liu Y.   +8 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A Reference-Free Algorithm Discovers Regulation in the Plant Transcriptome. [PDF]

Plant Direct
Meyer E, Saldivar EV, Kokot M, Xue B, Deorowicz S, Rhee SY, Salzman J.   +6 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Investigating the mechanisms by which bisphenol A affects osteoarthritis through a novel network toxicology framework and experimental validation. [PDF]

BMC Pharmacol Toxicol
He Q, Li S, Chen Y, Liu Y, Li Y, Min S, Yi S, Li F, Zhou X.   +8 more
europepmc   +1 more source

Intracellular Urokinase uPA-PAl-1 Complex: Disruption by Small Molecule Targets Hypoxically Programmed Glioma Cells [PDF]

Open Access Journal of Neurology & Neurosurgery, 2018
openaire   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source