Results 11 to 20 of about 2,545,393 (299)

eIF4E3 Forms an Active eIF4F Complex during Stresses (eIF4F ^S ) Targeting mTOR and Re-Programs the Translatome [PDF]

Nucleic Acids Research, 2021
ABSTRACT The eIF4E are a family of initiation factors that bind the mRNA 5’ cap, regulating the proteome and the cellular phenotype. eIF4E1 mediates global translation and its activity is controlled via the PI3K/AKT/mTOR pathway. mTOR down-regulation results in eIF4E1 sequestration into an inactive complex with the 4E
Benjamin Weiss, George Edward Allen, Joachim Kloehn, Karim Abid, Pascale Jaquier-Gubler, Joseph Alphonsus Curran   +5 more
openaire   +4 more sources

LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer [PDF]

Cell, 2009
Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the Mi-2/nucleosome remodeling and deacetylase (NuRD) complex. Transcriptional target analysis revealed that the LSD1/NuRD complexes regulate several cellular
Wang, Yan, Zhang, Hua, Chen, Yupeng, Sun, Yimin, Yang, Fen, Yu, Wenhua, Liang, Jing, Sun, Luyang, Yang, Xiaohan, Shi, Lei, Li, Ruifang, Li, Yanyan, Zhang, Yu, Li, Qian, Yi, Xia, Shang, Yongfeng   +15 more
openaire   +2 more sources

Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder [PDF]

Frontiers in Neuroscience, 2021
Introduction: Movement disorders can be common, persistent, and debilitating sequelae of severe traumatic brain injury. Post-traumatic movement disorders are usually complex in nature, involving multiple phenomenological manifestations, and can be difficult to control with medical management alone.
Ron Gadot, Ben Shofty, Ricardo A. Najera, Adrish Anand, Garrett Banks, Abdul Basit Khan, Melissa A. LoPresti, Nora Vanegas Arroyave, Sameer A. Sheth   +8 more
openaire   +3 more sources

Programmed shape-morphing into complex target shapes using architected dielectric elastomer actuators

Science Advances, 2022
Dielectric elastomer actuators (DEAs) are among the fastest and most energy-efficient, shape-morphing materials. To date, their shapes have been controlled using patterned electrodes or stiffening elements. While their actuated shapes can be analyzed for prescribed configurations of electrodes or stiffening elements (the forward problem), the design of
Ehsan Hajiesmaili, Natalie M. Larson, Jennifer A. Lewis, David R. Clarke   +3 more
openaire   +2 more sources

Evaluation design for a complex intervention program targeting loneliness in non-institutionalized elderly Dutch people [PDF]

BMC Public Health, 2010
The aim of this paper is to provide the rationale for an evaluation design for a complex intervention program targeting loneliness among non-institutionalized elderly people in a Dutch community. Complex public health interventions characteristically use the combined approach of intervening on the individual and on the environmental level.
de Vlaming, R., Haveman-Nies, A., van 't Veer, P., de Groot, C.P.G.M.   +3 more
openaire   +4 more sources

Computable features required to evaluate the efficacy of drugs and a universal algorithm to find optimally effective drug in a drug complex.

PLoS ONE, 2012
BackgroundThe H1N1 pandemic in 2009 and the H5N1 pandemic in 2005 demonstrated that the drugs approved to treat influenza A viruses have low efficacy. This provided a stimulus for new studies of influenza A viruses in the context of the methods used in ...
Kui Wang, Wei Cui, Gang Hu, Jianzhao Gao, Zhonghua Wu, Xingye Qiu, Jishou Ruan, Yi Feng, Zhi Qi, Yiming Shao, Jack A Tuszynski   +10 more
doaj   +1 more source

The features of state and municipal management of the development of single-industry settlements in the Arctic zone of the Russian Federation [PDF]

Арктика и Север, 2017
The article considers the current system of management of the development of single-industry settlements in the Arctic zone of the Russian Federation, the tools of strategic and program-target management of the development of single-industry cities are ...
Evgeniy E. Plisetskiy, Ekaterina A. Malitskaya   +1 more
doaj   +1 more source

A Multiple Radar Approach for Automatic Target Recognition of Aircraft using Inverse Synthetic Aperture Radar [PDF]

, 2018
Along with the improvement of radar technologies, Automatic Target Recognition (ATR) using Synthetic Aperture Radar (SAR) and Inverse SAR (ISAR) has come to be an active research area.
Cantu, Angel, Cantu, Elifaleth, Castellanos, Osvaldo, Gonzales, Adolfo, Kim, Dongchul, Pena-Caballero, Carlos, Rodriguez, Jesus, Son, Jae, Strait, Megan   +8 more
core   +3 more sources

Interim assessment of the degree of achievement of the planned indicators of the Federal target program «Research and development in priority areas of development of the scientific and technological complex of Russia for 2014–2020»

Ekonomika Nauki, 2019
The article summarizes the results of the interim assessment of the degree of achievement of the planned indicators of the Federal target program «Research and development in priority areas of development of the scientific and technological complex of ...
V. B. Mikhailets, I. V. Radin, K. V. Shurtakov   +2 more
doaj   +1 more source

The broad band spectral properties of galactic X-ray binary pulsars [PDF]

, 1998
BeppoSAX observed several galactic binary X-ray pulsars during the Science Verification Phase and in the first year of the regular program. The complex emission spectra of these sources are an ideal target for the BeppoSAX instrumentation, that can ...
A. Santangelo, A. Segreto, A.N. Parmar, Araya, Boella, Boella, D. Dal Fiume, Dal Fiume, F. Frontera, Frontera, Grove, M. Orlandini, Manzo, Mihara, Mészáros, Mészáros, Orlandini, Orlandini, Parmar, S. Del Sordo, S. Piraino, T. Oosterbroek, Tanaka, White   +23 more
core   +2 more sources