Results 221 to 230 of about 2,545,393 (299)

Online supervised learning of temporal patterns in biological neural networks under feedback control. [PDF]

Proc Natl Acad Sci U S A
Sono Y, Yamamoto H, Nishi Y, Sumi T, Sato Y, Hirano-Iwata A, Katori Y, Sato S.   +7 more
europepmc   +1 more source

PROGRAM-TARGET APPROACH TO THE FORMATION PLANS OF RESEARCH, DEVELOPMENT AND PRODUCTION OF COMPLEX TECHNICAL AND HUMAN-MACHINE SYSTEMS

Radioelectronics. Nanosystems. Information Technologies., 2015
openaire   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Crop Pest Identification and Real-Time Monitoring System Design Based on Improved YOLOv8s. [PDF]

Sensors (Basel)
Gao Q, Shi C, Ji Y, Wang M.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Preliminary Anti-Melanoma Activity of a Chlorogenic Acid-Based PROTAC Targeting MDM4, a Candidate Protein Identified by Proteomics. [PDF]

Foods
Mei Z, Sun J, Zhao P, Luo Y, Niu J, Huang D.   +5 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Repurposing FDA-approved drugs as multi-target neuroprotective agents for Alzheimer's disease via computational screening and experimental validation. [PDF]

Sci Rep
Phemphunananchai K, Waiwut P, Phetcharaburanin J, Poonsawas P, Boonyarat C.   +4 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Artificial intelligence-based screening of phytochemicals for targeted cancer therapy. [PDF]

Nat Prod Bioprospect
Santiago LR, Asevedo EA, de Oliveira MEJ, Pereira KC, da Silva Trindade MF, Oliveira AGS, Rocha MA, Kang S, Rani A, Park MN, Tan MW, Tan MW, Syahputra RA, Kim B, de Azambuja Ribeiro RIM.   +14 more
europepmc   +1 more source