Results 251 to 260 of about 2,545,393 (299)

Rapid directed evolution guided by protein language models and epistatic interactions. [PDF]

open access: yesScience
Tran VQ   +8 more
europepmc   +1 more source
Some of the next articles are maybe not open access.

Soft target and functional complexity reduction: A hybrid regularization method for genetic programming

Expert Systems with Applications, 2021
Abstract Regularization is frequently used in supervised machine learning to prevent models from overfitting. This paper tackles the problem of regularization in genetic programming. We apply, for the first time, soft target regularization, a method recently defined for artificial neural networks, to genetic programming.
Leonardo Vanneschi, Mauro Castelli
openaire   +1 more source

ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis [PDF]

open access: yesGenes and Development, 2017
The oncogenic transcription factor TAL1/SCL induces an aberrant transcriptional program in T-cell acute lymphoblastic leukemia (T-ALL) cells. However, the critical factors that are directly activated by TAL1 and contribute to T-ALL pathogenesis are largely unknown.
Shi Hao Tan   +2 more
exaly   +5 more sources

DEVELOPMENT OF THE AGRO-INDUSTRIAL COMPLEX OF THE REPUBLIC OF SOUTH OSSETIA WITHIN THE FRAMEWORK OF TARGETED PROGRAMS

EKONOMIKA I UPRAVLENIE: PROBLEMY, RESHENIYA, 2023
The development of each branch of the national economy should be carried out in the mode of effective planning. A necessary attribute is the presence of target indicators calculated on the principles of objectivity and scientific validity. Sectoral targeted programs are the very tool for long-term forecasting, which reflect the amount of necessary ...
Elkan Yu. Kharebov, Elena M. Dzudtsova
openaire   +1 more source

State Management of Socio-Economic Processes of the Agro-Industrial Complex on the Basis of a Program-Targeted Approach

Science Outpost, 2022
Development strategy of agricultural sector of the region is a constantly evolving management process aimed at organizing and functioning of agro-industrial complex, increasing stability and sustainability in order to solve food problem of the state.
Natalya A. Lytneva   +2 more
openaire   +1 more source

Abstract PO-021: Targeting the mitochondrial pyruvate complex to alter metabolic programming in pancreatic cancer

Cancer Research, 2021
Abstract Pancreatic ductal adenocarcinoma (PDAC) can be stratified into distinct transcriptome subtypes, with the ‘basal-like’ or ‘squamous’ subtype being associated with worse prognosis, compared to the ‘classical’ subtype. Our group recently demonstrated that PDAC tumors have unique metabolic transcriptome profiles, and that genes ...
Hassan A. Ali   +6 more
openaire   +1 more source

Allocating Weapons to Target Complexes by Means of Nonlinear Programming

Operations Research, 1966
The paper presents a three-stage method of assigning weapons to targets and illustrates its application with a small sample problem. The method decomposes the general allocation problem into a set of targeting problems in the small and a targeting problem in the large.
openaire   +1 more source

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