Results 101 to 110 of about 120,205 (311)

Do Firms Have a Target Leverage? Evidence from Credit Markets

, 2010
The static tradeoff theory of capital structure hypothesizes that firms have a target leverage which optimizes firm value in the presence of benefits and costs of leverage (such as taxes and bankruptcy costs). If firms adjust their actual leverage toward
Redouane Elkamhi, Raunaq S. Pungaliya, M. Vijh   +2 more
core  

The effect of tax planning, company value, and leverage on income smoothing practices in companies listed on Jakarta Islamic Index

Journal of Islamic Accounting and Finance Research, 2019
Purpose - The purpose of this paper is to identify the effect of tax planning, company value, and leverage on income smoothing practice in companies listed on the Jakarta Islamic Index for the period 2010-2017.
Novia Megarani, Warno Warno, Muchammad Fauzi   +2 more
doaj   +1 more source

Leveraging chromatin packing domains to target chemoevasion in vivo

Proceedings of the National Academy of Sciences
Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications and restructuring of topologically associating domains.
Jane Frederick, Ranya K. A. Virk, I Chae Ye, Luay M. Almassalha, Greta M. Wodarcyk, David VanDerway, Ruyi Gong, Cody L. Dunton, Tiffany Kuo, Karla I. Medina, Margarita Loxas, Jared T. Ahrendsen, Demirkan B. Gursel, Paola Carrillo Gonzalez, Rikkert J. Nap, Saira John, Vasundhara Agrawal, Nicholas M. Anthony, John Carinato, Wing Shun Li, Rivaan Kakkaramadam, Surbhi Jain, Shohreh Shahabi, Guillermo A. Ameer, Igal G. Szleifer, Vadim Backman   +25 more
openaire   +3 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Large dividend increases and leverage [PDF]

, 2018
This study documents the fact that large dividend increases are followed by a significant increase in leverage, consistent with management increasing the dividend to use up excess debt capacity.
Cooper, I A, Ian A. Cooper, Neophytos Lambertides, Lambertides, N, Cooper, Ian A., Lambertides, Neophytos   +5 more
core   +1 more source

Leveraging HER2-targeted biparatopic antibodies in solid tumors

Pharmacological Research
Biparatopic antibodies (bpAbs), which target non-overlapping epitopes on the same antigen, offer unique mechanisms of action and therapeutic applications that surpass those of conventional monospecific antibodies. These distinctive properties have positioned bpAbs as effective therapeutic agents in the treatment of cancer and infectious diseases ...
Xinlin Liu, Xinyi Fan, Xiang Gao, Weiyu Hu, Peng Sun   +4 more
openaire   +3 more sources

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

Effects of credit rating changes on capital structure of Latin American firms

Revista de Contabilidade e Organizações, 2019
This study investigates whether non-financial Latin American firms adjust their capital structure in order to maintain certain rating levels. The credit rating-capital structure (CR-CS) hypothesis suggests that firms assume less debt after rating ...
Thiago Botta Paschoal, Matheus da Costa Gomes, Mauricio Ribeiro do Valle   +2 more
doaj   +1 more source

Leveraging PARP-1/2 to Target Distant Metastasis

International Journal of Molecular Sciences
Poly (ADP-Ribose) Polymerase (PARP) inhibitors have changed the outcomes and therapeutic strategy for several cancer types. As a targeted therapeutic mainly for patients with BRCA1/2 mutations, PARP inhibitors have commonly been exploited for their capacity to prevent DNA repair.
Mallory I. Frederick, Djihane Abdesselam, Anna Clouvel, Laurent Croteau, Saima Hassan   +4 more
openaire   +2 more sources

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source