Results 131 to 140 of about 120,205 (311)
Understanding local immunity to enable regionalized medicine
The EMBO JournalThe adaptation of immune cells to their local microenvironments in our body is central to tissue homeostasis and linked to disease. In this commentary, we envision how future therapeutics could leverage local immunity to selectively target specific ...
Marco De Giovanni +2 more
doaj +1 more source
Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up
Arthritis Care &Research, EarlyView.Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker +14 more
wiley +1 more source
Capital Structure Decisions: Which Factors are Reliably Important?
This paper examines the relative importance of many factors in the capital structure decisions of publicly traded American firms from 1950 to 2003.
Goyal, Vidhan K., Frank, Murray Z.
core
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer +4 more
wiley +1 more source
Capital structure dynamics of US-based multinationals (MNCs) and domestic (DCs) firms
, 2012 This thesis is an empirical investigation of three related capital structure dynamics of US-based multinationals and their domestic counterparts. Specifically, the thesis examined whether there are differences in capital structure adjustment speed ...
Camara, Omar
core
A Self‐Supervised Framework for Refined Reconstruction of Geophysical Fields via Domain Adaptation
Earth and Space ScienceReconstructing fine‐grained, detailed spatial structures from time‐evolving coarse‐scale geophysical fields has been a long‐standing challenge. Current deep learning approaches addressing this issue generally require massive fine‐scale fields as ...
Liwen Wang +4 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu +2 more
wiley +1 more source
, 2012 Empirical findings and theoretical studies suggest that firms adjust toward time-varying target leverage ratios. This paper studies the performances of the default probabilities generated from two structural credit risk models (one with time-dependent ...
Wong, T, Huang, N, Hui, C, Lo, C
core
The influence of leveraged buyouts on target firms' competitors [PDF]
, 2015 This paper analyzes the influence Leveraged Buyouts (LBOs) have on the operating performance of the LBO target companies' direct competitors. A unique and hand-collected data set on LBOs in the United States in the period 1985-2009 allows us to analyze the effects different restructuring activities as part of the LBO have on the competitors' revenues ...
Grupp, Marcel +3 more
openaire +1 more source