Results 61 to 70 of about 461,783 (265)

Reliability-Based Design Optimisation of Bridge Systems Within BIM—Robustness, Redundancy and Safety Metrics

Buildings
Research shows that structures are often over designed in reliability-based calculations compared to code requirements. To address the knowledge gap in applying Reliability Based Design Optimisation (RBDO) within Building Information Modelling (BIM ...
John Dixon, Van Bac Nguyen, Boris Ceranic   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Maximizing Network Lifetime of Directional Sensor Networks Considering Coverage Reliability

International Journal of Distributed Sensor Networks, 2013
Directional sensor networks composed of a large number of directional sensors equipped with a limited battery and with a limited angle of sensing have recently attracted attention. Maximizing network lifetime is a challenge in developing energy-efficient
Joon-Min Gil, Jong Hyuk Park, Young-Sik Jeong   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Target reliability of civil engineering structures

IOP Conference Series: Materials Science and Engineering, 2018
The structural reliability recommended in Eurocodes and other international documents vary within a broad range, while the reference to the failure consequences and design working life is mentioned only very vaguely. In some cases the target reliability indexes are indicated for one or two reference periods (in Eurocodes for 1 year and 50 years ...
openaire   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

RMLNet—A Reliable Wireless Network for a Multiarea TDOA-Based Localization System

Sensors, 2019
Ultrawideband (UWB) wireless communication is a promising spread-spectrum technology for accurate localization among devices characterized by a low transmission power, a high rate and immunity to multipath propagation.
Yuan Xue, Wei Su, Dong Yang, Hongchao Wang, Weiting Zhang   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Substantiation of the Replacement Interval of Construction Machines by the Target Reliability Level

Architecture and Engineering, 2017
The article presents results of researches in the field of ensuring operational capability of complex technical objects using the example of construction machines.
Sergey Repin, Andrej Zazykin, Natalya Krotova   +2 more
doaj   +1 more source