Results 41 to 50 of about 190,073 (224)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Reliability analysis of welded and bolted connections in cold-formed steel sections
REM: International Engineering JournalThis article shows a study of the level of reliability of welded and bolted connections in cold formed steel members, for some limiting states, adopted by AISI and Brazilian codes.
Marcílio Sousa da Rocha Freitas +2 more
doaj +1 more source
Reliability Analysis for the Bending Strength of Larch 2×4 Lumber
BioResources, 2014 A safety analysis for Larch (Larix gmelinii) 2×4 lumber, based on the requirements of Chinese national standards, is presented in this paper. Static, third-point bending tests were conducted using an MTS universal testing machine.
Yong Zhong, Haiqing Ren
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calculation method for target reliability of natural gas pipeline systems
You-qi chuyunObjective The natural gas pipelines are large-scale, intricate, and open systems composed of multiple units, with a specialized focus on ensuring safe and reliable operation. Intensive research on pipeline system reliability has been conducted, gradually
Guangyu YAO +5 more
doaj +1 more source
Advances in Mechanical Engineering, 2016 In order to reduce the design variable fluctuations in the multi-objective optimization of the pantograph geometric parameters of electric multiple units, a multi-objective reliability design optimization method was proposed based on the dual response ...
Bingzhi Chen +3 more
doaj +1 more source
Advances in Mechanical Engineering, 2022 To improve the evaluation efficiency of failure probability in RBDO models with uncertainty, many RIA-based, PMA-based methods have evolved as a powerful procedure, including the modified reliability index approach (MRIA), PMA two-level, PMA with ...
Xue An, Dongyan Shi
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Cost-optimization based target reliabilities for design of structures exposed to fire
Resilient Cities and StructuresAdequacy of structural fire design in uncommon structures is conceptually ensured through cost-benefit analysis where the future costs are balanced against the benefits of safety investment.
Ranjit Kumar Chaudhary +2 more
doaj +1 more source