Results 71 to 80 of about 190,073 (224)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Zhongwai GongluAiming at the high-precision reconstruction of structural function functions caused by the strong nonlinearity of cable load-bearing bridge structures, this study presented a structural system reliability analysis method based on a deep belief network ...
CHEN Zhenyu, XIE Bo, LU Naiwei
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Reliability Assessment of Simply Supported Beam Bridge Structural Performance Based on Load Tests
Advances in Civil EngineeringCurrently, bridge load tests use the verification coefficient to evaluate the structural performance of bridges in China, but this method is unsuitable.
Xuzheng Liu +5 more
doaj +1 more source
, 2021 Target reliability levels recommended in various national and international documents are inconsistent. In various sources, they are determined depending on the relative costs of safety measures, the consequences of failure, the risk to life, discount rate, etc.
openaire +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Pile design practice in southern Africa Part 2: Implicit reliability of existing practice
Journal of the South African Institution of Civil Engineers, 2013 Limit state design has become the basis of geotechnical design codes worldwide. With the semi-probabilistic limit state design approach, load and resistance factors of (deterministic) design functions are calibrated on the basis of reliability theory ...
J V Retief, M Dithinde
doaj
Calibration of Undrained Shear Strength Partial Factor Using Probability Theory
Tehnički Glasnik, 2022 Design in accordance with Eurocode 7 applies the partial factors of geotechnical parameters to take into account uncertainties of various sources.
Filip Dodigović +3 more
doaj
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A general novel process capability index for normal and non-normal measurements
Ain Shams Engineering JournalIn this study, a new process capability index is proposed. The new index is quantile-based, can be used in normal and non-normal measurements, and is a general form of the conventional Cpm.
Kadir Karakaya
doaj +1 more source