Results 241 to 250 of about 8,510,768 (280)

Novel target sites in bacteria for overcoming antibiotic resistance

Advanced Drug Delivery Reviews, 2005
Resistance to marketed antibiotics continues to increase. During the last 10 years some 200 bacterial genome sequences have become available, giving rise to expectations that genomics would provide a plethora of novel targets and hence a flood of new therapeutic agents.
Michael T, Black, John, Hodgson
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Target-site and non-target-site-based resistance to tribenuron-methyl in multiply-resistant Myosoton aquaticum L.

Pesticide Biochemistry and Physiology, 2019
Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to both herbicides had evolved.
Shuang, Bai, Fengwen, Zhang, Zuren, Li, Hengzhi, Wang, Qian, Wang, Jinxin, Wang, Weitang, Liu, Lianyang, Bai   +7 more
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Cross-resistance to photosystem II inhibitors observed in target site–resistant but not in non–target site resistant common ragweed (Ambrosia artemisiifolia)

Weed Science, 2022
AbstractThe full spectrum of herbicide resistance in a weed can vary according to the mechanistic basis and cannot be implied from the selective pressure. Common ragweed (Ambrosia artemisiifolia L.) is an important weed species of horticultural crops that has developed resistance to linuron based on either target site– or non–target site resistance ...
Martin Laforest, Marie-Josée Simard, Sydney Meloche, Lydia Maheux, François Tardif, Eric Page   +5 more
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Target and non‐target site mechanisms of fungicide resistance and their implications for the management of crop pathogens

Pest Management Science, 2023
Abstract Fungicides are indispensable for high‐quality crops, but the rapid emergence and evolution of fungicide resistance have become the most important issues in modern agriculture. Hence, the sustainability and profitability of agricultural production have been challenged due to the limited number of fungicide chemical classes ...
Adriano Francis Dorigan, Silvino Intra Moreira, Sarah da Silva Costa Guimarães, Valter Cruz‐Magalhães, Eduardo Alves   +4 more
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Target-site and non-target-site resistance mechanisms confer mesosulfuron-methyl resistance in Alopecurus aequalis

Plant Physiology and Biochemistry
Shortawn foxtail (Alopecurus aequalis Sobol.) is a noxious weed in China. The resistance of A. aequalis developed rapidly due to the long-term application of acetolactate synthase (ALS)-inhibiting herbicides. Here, a suspected mesosulfuron-methyl-resistant A.
You Zhan, Haozhe Liu, Ziheng Cao, Jiale Qi, Lianyang Bai, Lang Pan   +5 more
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Altered target sites as a mechanism of herbicide resistance

Crop Protection, 2000
Abstract Over 200 distinct herbicide resistant weed biotypes have evolved worldwide. In most of these, resistance is conferred by an altered target site, i.e. a modified target protein with reduced affinity for the herbicide(s) in question. This has been documented for herbicides that target most major known sites of action, including those that ...
Malcolm D. Devine, Amit Shukla
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Non-target Site Mechanisms of Resistance to Herbicides

Critical Reviews in Plant Sciences, 2017
ABSTRACTEvolution of resistance in weeds to herbicides is threatening world agricultural production. Weed management has become more complicated with the development of non-target site resistance (NTSR) to herbicides in weeds. The NTSR mechanisms can be caused by herbicide metabolism, altered patterns of translocation, and herbicide absorption ...
Hossein Ghanizadeh, Kerry C. Harrington
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Overcoming drug resistance: targeting more than one site

Leukemia Research, 2002
Activation of the molecular machinery of programmed cell death (apoptosis) is a convergence point for many cytotoxic agents, irrespective of the primary mechanism of action. Indeed, apoptosis is induced in response to DNA strand breaks caused by such mechanistically diverse anti-leukemic drugs as the nucleoside cytosine arabinoside (ara-C ...
Judith E, Karp, Bijoyesh P, Mookerjee
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R-factor trimethoprim resistance mechanism: An insusceptible target site

Biochemical and Biophysical Research Communications, 1974
Abstract R-factor R388 increases the resistance of Escherichia coli to trimethoprim by 10,000 fold, and mediates the synthesis of an addional dihydrofolate reductase that is less susceptible to trimethoprim by a similar order of magnitude. The dihydrofolate reductase conferred by the R-factor was of a larger molecular weight than the wild-type ...
S G, Amyes, J T, Smith
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Conyza bonariensis resistance to glyphosate and ALS inhibitors involves target and non-target site resistance

Pesticide Biochemistry and Physiology
Herbicide resistance in Conyza bonariensis (hairy fleabane) poses a significant challenge to agricultural systems worldwide. The genetic variability and prolific seed production of this species contribute significantly to its adaptative potential and fast spread in the agricultural fields.
Tiago Edu, Kaspary, Luan, Cutti, Guilherme Menegol, Turra, Paula Sinigaglia, Angonese, Othon Dias, Dos Santos, Aldo, Merotto   +5 more
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