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Non-target-site herbicide resistance: a family business
Trends in Plant Science, 2007We have witnessed a dramatic increase in the frequency and diversity of herbicide-resistant weed biotypes over the past two decades, which poses a threat to the sustainability of agriculture at both local and global levels. In addition, non-target-site mechanisms of herbicide resistance seem to be increasingly implicated.
Joshua S, Yuan +2 more
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Novel target sites in bacteria for overcoming antibiotic resistance
Advanced Drug Delivery Reviews, 2005Resistance to marketed antibiotics continues to increase. During the last 10 years some 200 bacterial genome sequences have become available, giving rise to expectations that genomics would provide a plethora of novel targets and hence a flood of new therapeutic agents.
Michael T, Black, John, Hodgson
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2023
Resistance to iodosulfuron, a herbicide targeting acetolactate synthase (ALS), was identified and characterised in a population of Lolium perenne L. from Canterbury, New Zealand. The resistant population was 264 times more resistant to iodosulfuron than a susceptible population, based on a ratio of the rate corresponding to a 50% reduction in resistant
Ghanizadeh, Hossein +4 more
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Resistance to iodosulfuron, a herbicide targeting acetolactate synthase (ALS), was identified and characterised in a population of Lolium perenne L. from Canterbury, New Zealand. The resistant population was 264 times more resistant to iodosulfuron than a susceptible population, based on a ratio of the rate corresponding to a 50% reduction in resistant
Ghanizadeh, Hossein +4 more
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Weed Science, 2022
AbstractThe full spectrum of herbicide resistance in a weed can vary according to the mechanistic basis and cannot be implied from the selective pressure. Common ragweed (Ambrosia artemisiifolia L.) is an important weed species of horticultural crops that has developed resistance to linuron based on either target site– or non–target site resistance ...
Martin Laforest +5 more
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AbstractThe full spectrum of herbicide resistance in a weed can vary according to the mechanistic basis and cannot be implied from the selective pressure. Common ragweed (Ambrosia artemisiifolia L.) is an important weed species of horticultural crops that has developed resistance to linuron based on either target site– or non–target site resistance ...
Martin Laforest +5 more
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Pest Management Science, 2023
Abstract Fungicides are indispensable for high‐quality crops, but the rapid emergence and evolution of fungicide resistance have become the most important issues in modern agriculture. Hence, the sustainability and profitability of agricultural production have been challenged due to the limited number of fungicide chemical classes ...
Adriano Francis Dorigan +4 more
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Abstract Fungicides are indispensable for high‐quality crops, but the rapid emergence and evolution of fungicide resistance have become the most important issues in modern agriculture. Hence, the sustainability and profitability of agricultural production have been challenged due to the limited number of fungicide chemical classes ...
Adriano Francis Dorigan +4 more
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Bacterial resistance to antibiotics: Modified target sites
Advanced Drug Delivery Reviews, 2005Alteration in the target sites of antibiotics is a common mechanism of resistance. Examples of clinical strains showing resistance can be found for every class of antibiotic, regardless of the mechanism of action. Target site changes often result from spontaneous mutation of a bacterial gene on the chromosome and selection in the presence of the ...
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Altered target sites as a mechanism of herbicide resistance
Crop Protection, 2000Abstract Over 200 distinct herbicide resistant weed biotypes have evolved worldwide. In most of these, resistance is conferred by an altered target site, i.e. a modified target protein with reduced affinity for the herbicide(s) in question. This has been documented for herbicides that target most major known sites of action, including those that ...
Malcolm D. Devine, Amit Shukla
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Non-target Site Mechanisms of Resistance to Herbicides
Critical Reviews in Plant Sciences, 2017ABSTRACTEvolution of resistance in weeds to herbicides is threatening world agricultural production. Weed management has become more complicated with the development of non-target site resistance (NTSR) to herbicides in weeds. The NTSR mechanisms can be caused by herbicide metabolism, altered patterns of translocation, and herbicide absorption ...
Hossein Ghanizadeh, Kerry C. Harrington
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R-factor trimethoprim resistance mechanism: An insusceptible target site
Biochemical and Biophysical Research Communications, 1974Abstract R-factor R388 increases the resistance of Escherichia coli to trimethoprim by 10,000 fold, and mediates the synthesis of an addional dihydrofolate reductase that is less susceptible to trimethoprim by a similar order of magnitude. The dihydrofolate reductase conferred by the R-factor was of a larger molecular weight than the wild-type ...
S G, Amyes, J T, Smith
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Overcoming drug resistance: targeting more than one site
Leukemia Research, 2002Activation of the molecular machinery of programmed cell death (apoptosis) is a convergence point for many cytotoxic agents, irrespective of the primary mechanism of action. Indeed, apoptosis is induced in response to DNA strand breaks caused by such mechanistically diverse anti-leukemic drugs as the nucleoside cytosine arabinoside (ara-C ...
Judith E, Karp, Bijoyesh P, Mookerjee
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