Results 161 to 170 of about 630,172 (289)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae

, 2014
Sara N. Mitchell, Daniel J. Rigden, Andrew Dowd, Fang Lu, Craig S. Wilding, David Weetman, Samuel Dadzie, Adam M. Jenkins, Kimberly Regna, Pélagie Boko, Luc Djogbénou, Marc A. T. Muskavitch, Hilary Ranson, Mark J. I. Paine, Olga Mayans, Martin J. Donnelly   +15 more
openalex   +2 more sources

Increased metabolism in combination with the novel cytochrome b target-site mutation L258F confers cross-resistance between the Qo inhibitors acequinocyl and bifenazate in Tetranychus urticae

, 2023
Xue‐Ping Lu, Marilou Vandenhole, Dimitra Tsakireli, Spiros A. Pergantis, John Vontas, Wim Jonckheere, Thomas Van Leeuwen   +6 more
openalex   +2 more sources

Echinochloa colona with Reported Resistance to Glyphosate Conferred by Aldo-Keto Reductase Also Contains a Pro-106-Thr EPSPS Target Site Mutation [PDF]

, 2020
J. Scott McElroy, Nathan D. Hall
openalex   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Multiple insecticide resistance target sites in adult field strains of An. gambiae s.l. from southeast Senegal. [PDF]

, 2020
El Hadji Diouf, El Hadji Amadou Niang, Badara Samb, Cheikh Tidiane Diagne, Mbaye Diouf, Abdoulaye Konaté, Ibrahima Dia, Ousmane Faye, Lassana Konaté   +8 more
openalex   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Study on the molecular mechanism of non-target-site resistance in several paddy weeds

, 2015
Satoshi Iwakami
openalex   +2 more sources

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source