Results 161 to 170 of about 1,394,726 (329)

Development of molecular assays to detect target-site mechanisms associated with insecticide resistance in malaria vectors from Latin America [PDF]

, 2019
Juan C. Lol, David Castañeda, Lucy Mackenzie-Impoinvil, C. García Romero, Audrey Lenhart, Norma Padilla   +5 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evolution of the Pyrethroids Target-Site Resistance Mechanisms in Senegal: Early Stage of the <i>Vgsc-1014F</i> and <i>Vgsc-1014S</i> Allelic Frequencies Shift. [PDF]

Genes (Basel), 2021
Diallo M, Hamid-Adiamoh M, Sy O, Sarr PC, Manneh J, Ndiath MO, Gaye O, Faye O, Konaté L, Sesay AK, Assogba BS, Niang EHA.   +11 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Additional file 2: Table S1. of Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance

, 2017
Shu-Jung Lai, I-Fan Tu, Wan‐Ling Wu, Jhih-Tian Yang, Louis Luk, Mei‐Chin Lai, Yu-Hsuan Tsai, Shih-Hsiung Wu   +7 more
openalex   +1 more source

Multiple insecticide resistance target sites in adult field strains of An. gambiae (s.l.) from southeastern Senegal [PDF]

, 2020
El Hadji Diouf, El Hadji Amadou Niang, Badara Samb, Cheikh Tidiane Diagne, Mbaye Diouf, Abdoulaye Konaté, Ibrahima Dia, Ousmane Faye, Lassana Konaté   +8 more
openalex   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Distribution of target site PPO-inhibiting herbicide resistance mutations in waterhemp and Palmer amaranth and association of epyrifenacil efficacy with PPX2 target site variants [PDF]

Jacob S. Montgomery, Daljit Singh, Andrew J. Tyre, J. M. Chittoor, Clifford Wollam, Brandi J Chiapelli, John A. Pawlak, Chandrashekar Aradhya, Alejandro Perez‐Jones   +8 more
openalex   +1 more source

Barlow-Hall in vitro Evolution Protocol [PDF]

, 2008
The Barlow-Hall method for in vitro evolution is a simple alternative to methods such as DNA shuffling and is particularly applicable to predicting the evolution of target genes in nature.
Barry G. Hall, Miriam Barlow
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source