Results 201 to 210 of about 655,521 (249)
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Bacterial resistance to antibiotics: Modified target sites
Advanced Drug Delivery Reviews, 2005Alteration in the target sites of antibiotics is a common mechanism of resistance. Examples of clinical strains showing resistance can be found for every class of antibiotic, regardless of the mechanism of action. Target site changes often result from spontaneous mutation of a bacterial gene on the chromosome and selection in the presence of the ...
Peter A. Lambert
exaly +3 more sources
Non-Target Site Mechanisms of Fungicide Resistance in Crop Pathogens: A Review
Microorganisms, 2021 The rapid emergence of resistance in plant pathogens to the limited number of chemical classes of fungicides challenges sustainability and profitability of crop production worldwide. Understanding mechanisms underlying fungicide resistance facilitates monitoring of resistant populations at large-scale, and can guide and accelerate the development of ...
Shuning Chen, Mengjun Hu
exaly +5 more sources
Pinoxaden resistance in Lolium perenne L. is due to both target-site and non-target-site mechanisms
Pesticide Biochemistry and Physiology, 2022Application of herbicides inhibiting acetyl CoA carboxylase (ACCase) has been one of the main strategies for selectively controlling grass weed species such as perennial ryegrass (Lolium perenne L.) in wheat and barley crops in New Zealand. In this study, we have confirmed and characterized resistance to pinoxaden, an ACCase-inhibiting herbicide, in a ...
Hossein, Ghanizadeh +4 more
openaire +2 more sources
Pesticide Biochemistry and Physiology, 2019
Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to both herbicides had evolved.
Shuang, Bai +7 more
openaire +2 more sources
Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to both herbicides had evolved.
Shuang, Bai +7 more
openaire +2 more sources
Novel target sites in bacteria for overcoming antibiotic resistance
Advanced Drug Delivery Reviews, 2005Resistance to marketed antibiotics continues to increase. During the last 10 years some 200 bacterial genome sequences have become available, giving rise to expectations that genomics would provide a plethora of novel targets and hence a flood of new therapeutic agents.
Michael T, Black, John, Hodgson
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Pesticide Biochemistry and Physiology, 2023
Wild oat (Avena fatua L.) is a common and problematic weed in wheat fields in China. In recent years, farmers found it increasingly difficult to control A. fatua using acetyl-CoA carboxylase (ACCase)-inhibiting herbicides. The purpose of this study was to identify the molecular basis of clodinafop-propargyl resistance in A. fatua.
Yujun, Han +6 more
openaire +2 more sources
Wild oat (Avena fatua L.) is a common and problematic weed in wheat fields in China. In recent years, farmers found it increasingly difficult to control A. fatua using acetyl-CoA carboxylase (ACCase)-inhibiting herbicides. The purpose of this study was to identify the molecular basis of clodinafop-propargyl resistance in A. fatua.
Yujun, Han +6 more
openaire +2 more sources
Mapping cryptic binding sites of drug targets to overcome drug resistance
Drug Resistance Updates, 2023The emergence of drug resistance is a primary obstacle for successful chemotherapy. Drugs that target cryptic binding sites (CBSs) represent a novel strategy for overcoming drug resistance. In this short communication, we explain and discuss how the discovery of CBSs and their inhibitors can overcome drug resistance.
Charles R Ashby
exaly +3 more sources