Results 51 to 60 of about 7,696,254 (202)

Ile-1781-Leu Target Mutation and Non-Target-Site Mechanism Confer Resistance to Acetyl-CoA Carboxylase-Inhibiting Herbicides in Digitaria ciliaris var. chrysoblephara

, 2023
Digitaria ciliaris var. chrysoblephara is a xerophytic weed severely invading rice fields along with the application of rice mechanical direct seeding technology in China.
Qian Yang (300330), Jinlei Zhu (15494526), Xia Yang (46748), Min Lv (608418), Tian Wei (5533379), Yongfeng Li (135567)   +5 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Detection of target-site and metabolic resistance to pyrethroids in the bed bug Cimex lectularius in Berlin, Germany11 Note: Supplementary data associated with this article.

International Journal for Parasitology: Drugs and Drug Resistance, 2020
Knockdown-resistance (kdr) against pyrethroids in bed bugs (Cimex lectularis) is associated with the presence of several point mutations in the voltage-sensitive sodium channel α-subunit gene and/or an increased metabolic detoxification by cytochrome ...
Arlette Vander Pan, Carola Kuhn, Erik Schmolz, Georg von Samson-Himmelstjerna, Jürgen Krücken   +4 more
doaj   +1 more source

Herbicide resistant weeds: the case of resistance to glyphosate

Vietnam Journal of Science, Technology and Engineering, 2022
Glyphosate has become the most widely used herbicide worldwide since 1974 with a global use of 8.6 billion kg (glyphosate active ingredient) between 1974 and 2014.
The Duc Ngo
doaj   +1 more source

Knockdown resistance to DDT and pyrethroids: from target-site mutations to molecular modelling

, 2008
Naturally derived insecticides such as pyrethrum and man-made insecticides such as DDT and the synthetic pyrethroids act on the voltage-gated sodium channel proteins found in insect nerve-cell membranes.
Field, L.M., Andrias O O'Reilly, Williamson, M.S., Wallace, Bonnie A., BA Wallace, Linda M Field, TG Emyr Davies, Wallace, B. A., Davies, T.G.E., O’Reilly, Andrias O., Field, L. M., O'Reilly, A. O., Davies, T. G. E., Martin S Williamson, Williamson, M. S., Davies, Emyr, Field, Lin, Williamson, Martin   +17 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Pinoxaden resistance in Lolium perenne L. is due to both target-site and non-target-site mechanisms

, 2022
Application of herbicides inhibiting acetyl CoA carboxylase (ACCase) has been one of the main strategies for selectively controlling grass weed species such as perennial ryegrass (Lolium perenne L.) in wheat and barley crops in New Zealand. In this study,
Hossein Ghanizadeh (9628392), Andrew Griffiths (3440687), Zachary Ngow (9028616), Chris Buddenhagen (15395984), Kerry Harrington (15394508)   +4 more
core  

Long-term trends in Anopheles gambiae insecticide resistance in Côte d'Ivoire [PDF]

, 2014
Malaria control is heavily dependent on the use of insecticides that target adult mosquito vectors via insecticide treated nets (ITNs) or indoor residual spraying (IRS).
Barry, Sarah, Bassirou Bonfoh, Barry, Sarah J.E., N'goran, Eliezer K., Chouaibou, Mouhamadou, Johnson, Paul, Eliezer K N’Goran, Louise Bellai, Adja, Akre M., Benjamin G Koudou, Akre M Adja, Dongus, Stefan, Ranson, Hilary, Edi, Constant A.V., N’Goran, Eliezer K., Weetman, David; id_orcid, Koudou, Benjamin G., Johnson, Paul C.D., Bonfoh, Bassirou, Pie Müller, Ranson, Hilary; id_orcid, Sarah JE Barry, Constant AV Edi, Edi, Constant, Müller, Pie, Paul CD Johnson, Stefan Dongus, David Weetman, Weetman, David, N. Goran, Eliezer K., Bellai, Louise, Mouhamadou Chouaibou, Hilary Ranson, Ranson H, Chouaibou M, Weetman D, Bellai L, Bonfoh B, Adja AM, Dongus S, N'Goran EK, Koudou BG, Edi CA, Müller P, Barry SJ, Johnson PC   +45 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Investigation and characterisation of diamide insecticide resistance conferred by target-site mutations in the Ryanodine Receptor of lepidopteran pests [PDF]

, 2019
Lepidopteran crop pests such as Tuta absoluta, Chilo suppressalis, Spodoptera frugiperda and Plutella xylostella are becoming increasingly problematic, as populations colonise new regions of the globe.
Richardson, E.
core