Results 81 to 90 of about 655,521 (249)

Resistance Mechanisms to Glyphosate in Lamarckia aurea (L.) Moench Found in Southern Spain

Agronomy
Glyphosate has been used for roadside weed control in southern Spain for over 40 years, and most populations of goldentop (Lamarckia aurea L.) Moench have putatively developed resistance to this active ingredient.
José Alfredo Domínguez-Valenzuela, Javid Gherekhloo, Candelario Palma-Bautista, Saeid Hassanpour-bourkheili, Guido Plaza, Antonia M. Rojano-Delgado, Rafael De Prado   +6 more
doaj   +1 more source

10,000-Times Diluted Doses of ACCase-Inhibiting Herbicides Can Permanently Change the Metabolomic Fingerprint of Susceptible Avena fatua L. Plants

Plants, 2019
Intentional use of low dosage of herbicides has been considered the cause of non-target resistance in weeds. However, herbicide drift could be a source of low dosage that could be detected by weeds and change their metabolism.
J António Tafoya-Razo, Ernesto Oregel-Zamudio, Sabina Velázquez-Márquez, Jesús R. Torres-García   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dose Splitting Increases Selection for Both Target‐Site and Non‐Target‐Site Fungicide Resistance—A Modelling Analysis

Plant Pathology
ABSTRACT Fungicide resistance management principles recommend that farmers avoid splitting the total dose applied of a fungicidal mode of action (MoA) across multiple applications per season (‘dose splitting’).
Isabel Corkley, Alexey Mikaberidze, Neil Paveley, Frank van den Bosch, Michael W. Shaw, Alice E. Milne   +5 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deep haplotype analyses of target-site resistance locus ACCase in blackgrass enabled by pool-based amplicon sequencing. [PDF]

Plant Biotechnol J, 2023
Kersten S, Rabanal FA, Herrmann J, Hess M, Kronenberg ZN, Schmid K, Weigel D.   +6 more
europepmc   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A high diversity of non-target site resistance mechanisms to acetolactate-synthase (ALS) inhibiting herbicides has evolved within and among field populations of common ragweed (Ambrosia artemisiifolia L.). [PDF]

BMC Plant Biol, 2023
Loubet I, Meyer L, Michel S, Pernin F, Carrère S, Barrès B, Le Corre V, Délye C.   +7 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source