Results 71 to 80 of about 1,167,859 (318)

Treatment of acute carbon monoxide poisoning with induced hypothermia [PDF]

Clinical and Experimental Emergency Medicine, 2016
Objective The effect of induced hypothermia on severe acute carbon monoxide (CO) poisoning remains to be addressed further. We investigated the effect of induced hypothermia on severe acute CO poisoning.
Byoung-Joon Oh, Yong-Gyun Im, Eunjung Park, Young-Gi Min, Sang-Cheon Choi   +4 more
doaj   +1 more source

Consensus recommendations on therapeutic hypothermia after minimally invasive intracerebral hemorrhage evacuation from the hypothermia for intracerebral hemorrhage (HICH) working group

Frontiers in Neurology, 2022
Background and purposeTherapeutic hypothermia (TH), or targeted temperature management (TTM), is a classic treatment option for reducing inflammation and potentially other destructive processes across a wide range of pathologies, and has been ...
Turner S. Baker, Turner S. Baker, Christopher P. Kellner, Frederick Colbourne, Fred Rincon, Rainer Kollmar, Rainer Kollmar, Neeraj Badjatia, Neha Dangayach, J. Mocco, Magdy H. Selim, Patrick Lyden, Kees Polderman, Stephan Mayer, Stephan Mayer, Stephan Mayer   +15 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Therapeutic hyperthermia for the treatment of infection—a narrative review

Frontiers in Physiology, 2023
Modulating body temperature, mostly through the use of antipyretics, is a commonly employed therapeutic intervention in medical practice. However, emerging evidence suggests that hyperthermia could serve as an adjuvant therapy for patients with infection.
Andrej Markota, Andrej Markota, Žiga Kalamar, Jure Fluher, Jure Fluher, Sergej Pirkmajer   +5 more
doaj   +1 more source

Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles. [PDF]

, 2015
Magnetic hyperthermia - a potential cancer treatment in which superparamagnetic iron oxide nanoparticles (SPIONs) are made to resonantly respond to an alternating magnetic field (AMF) and thereby produce heat - is of significant current interest. We have
Janes, SM, Kalber, TL, Kyrtatos, PG, Loebinger, MR, Lythgoe, MF, Ordidge, KL, Pankhurst, QA, Southern, P   +7 more
core   +2 more sources

Transient Global Ischemia-Induced Brain Inflammatory Cascades Attenuated by Targeted Temperature Management

International Journal of Molecular Sciences, 2021
Sudden cardiac arrest leads to a significantly increased risk of severe neurological impairment and higher mortality rates in survivors due to global brain tissue injury caused by prolonged whole-body ischemia and reperfusion. The brain undergoes various
D. Hong, Y. Park, J. Woo, J. Kim, J. Beom, S. Chung, J. You, S. Suh   +7 more
semanticscholar   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Therapeutic hypothermia and Type II errors: Do not throw out the baby with the ice water

Brain Circulation, 2019
After initial enthusiasm for mild therapeutic hypothermia (TH) treatment after brain injuries, including global cerebral ischemia after cardiac arrest, subsequent trials suggested similar benefit using only targeted temperature management (TTM), with ...
Patrick Lyden, Ariana Anderson, Padmesh Rajput   +2 more
doaj   +1 more source

Impacts of Climate Change on indirect human exposure to pathogens and chemicals from agriculture [PDF]

, 2008
Objective: Climate change is likely to affect the nature of pathogens and chemicals in the environment and their fate and transport. Future risks of pathogens and chemicals could therefore be very different from those of today.
Adhikari A, Alistair B.A. Boxall, Anthony Hardy, David B. Turley, David Stone, Edward Topp, Elizabeth M.H. Wellington, European Communities, Food and Agriculture Organization, Gale P, Giovanni Leonardi, Githecko AK, Gordon Nichols, Haines A, Hawkes C, Kerry Walsh, Laura Burgin, Laura Potts, Leonard S. Levy, Patterson DT, Peter D. Falloon, Philip M. Haygarth, R. Sari Kovats, Richard J. Williams, Sabine Beulke, Simon A. Parsons, Tatiana Boucard, Thomas Hutchinson, van den Berg H   +28 more
core   +6 more sources

Targeted temperature management and early neuro-prognostication after cardiac arrest

Journal of Cerebral Blood Flow and Metabolism, 2021
Targeted temperature management (TTM) is a recommended neuroprotective intervention for coma after out-of-hospital cardiac arrest (OHCA). However, controversies exist concerning the proper implementation and overall efficacy of post-CA TTM, particularly ...
Songyu Chen, B. Lachance, Liang Gao, X. Jia   +3 more
semanticscholar   +1 more source