Results 301 to 310 of about 10,998,800 (355)
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British Medical Bulletin, 1995
Melanin biosynthesis is limited to melanocytes partly as a consequence of transcriptional regulation of the enzymes involved in this pathway. Promoter sequences of these enzyme genes may be utilised to drive expression of complementary DNA coding for therapeutic genes so as to provide transcriptional targeting. We have used the 5'-flanking sequences of
I R, Hart, R G, Vile
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Melanin biosynthesis is limited to melanocytes partly as a consequence of transcriptional regulation of the enzymes involved in this pathway. Promoter sequences of these enzyme genes may be utilised to drive expression of complementary DNA coding for therapeutic genes so as to provide transcriptional targeting. We have used the 5'-flanking sequences of
I R, Hart, R G, Vile
openaire +2 more sources
Experimental Cell Research, 2011
Anti-Epidermal Growth Factor Receptor (EGFR) therapies have been recently developed for the treatment of multiple cancer types. At the time when they were introduced in clinical practice, there was little knowledge of the molecular bases of tumor sensitivity and resistance to these novel targeted compounds.
Vecchione L +4 more
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Anti-Epidermal Growth Factor Receptor (EGFR) therapies have been recently developed for the treatment of multiple cancer types. At the time when they were introduced in clinical practice, there was little knowledge of the molecular bases of tumor sensitivity and resistance to these novel targeted compounds.
Vecchione L +4 more
openaire +3 more sources
New England Journal of Medicine, 2004
The emergence of effective cancer chemotherapy is one of the major medical advances of the second half of the 20th century. In certain neoplasms — such as gestational choriocarcinoma, childhood acute lymphoblastic leukemia, and subgroups of Hodgkin's disease and non-Hodgkin's lymphoma — chemotherapy is often curative, and the promise of long-term ...
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The emergence of effective cancer chemotherapy is one of the major medical advances of the second half of the 20th century. In certain neoplasms — such as gestational choriocarcinoma, childhood acute lymphoblastic leukemia, and subgroups of Hodgkin's disease and non-Hodgkin's lymphoma — chemotherapy is often curative, and the promise of long-term ...
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Nature Reviews Drug Discovery, 2010
Oncology has become one of the major focus areas for pharmaceutical and biotechnology companies. In 2009, ~16,000 of the ~40,000 Phase I, II and III trials listed on ClinicalTrials.gov were related to cancer (~40%). This large interest stems from the existence of high unmet need for improved treatments of multiple types of cancer and the substantial ...
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Oncology has become one of the major focus areas for pharmaceutical and biotechnology companies. In 2009, ~16,000 of the ~40,000 Phase I, II and III trials listed on ClinicalTrials.gov were related to cancer (~40%). This large interest stems from the existence of high unmet need for improved treatments of multiple types of cancer and the substantial ...
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Signal Transduction and Targeted Therapy
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeutics.
Wei-wei Liu +8 more
semanticscholar +1 more source
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeutics.
Wei-wei Liu +8 more
semanticscholar +1 more source
Nature, 2004
Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die.
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Disruption of the normal regulation of cell-cycle progression and division lies at the heart of the events leading to cancer. Complex networks of regulatory factors, the tumour microenvironment and stress signals, such as those resulting from damaged DNA, dictate whether cancer cells proliferate or die.
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Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers.
Cancer metastasis reviews, 2023Yu Wang, B. Deng
semanticscholar +1 more source
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 2009
The definition of targets in the metastatic process has been a major step. Targeted therapy is composed of molecules which block these targets including ligand-binding antibody or receptor-inhibitors. Their mechanisms of action are not limited to angiogenesis but also concern apoptosis, bone marrow progenitor stem cells, vascularisation and immune ...
A, Méjean, T, Lebret
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The definition of targets in the metastatic process has been a major step. Targeted therapy is composed of molecules which block these targets including ligand-binding antibody or receptor-inhibitors. Their mechanisms of action are not limited to angiogenesis but also concern apoptosis, bone marrow progenitor stem cells, vascularisation and immune ...
A, Méjean, T, Lebret
openaire +1 more source
Targeted therapy for osteosarcoma: a review
Journal of Cancer Research and Clinical Oncology, 2023Shizhe Li +3 more
semanticscholar +1 more source