Results 341 to 350 of about 10,512,166 (412)

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

The potential and challenges of TREM2-targeted therapy in Alzheimer's disease: insights from the INVOKE-2 study. [PDF]

Front Aging Neurosci
Ma YN, Hu X, Karako K, Song P, Tang W, Xia Y.   +5 more
europepmc   +1 more source

The development of a novel Epstein Barr-Virus targeted adenoviral vector for cancer gene therapy

, 2000
J Li, Craig A. Strathdee, Henry J. Klamut, D P Huang, F. Liu   +4 more
openalex   +1 more source

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

Quality of life in patients with metastatic colorectal cancer receiving cytotoxic and cytotoxic plus targeted therapy. [PDF]

BMC Cancer
Pham HT, Nguyen TA, Ba TL, Tran VNM, Castelino RL, Truong-Nguyen KH, Nguyen BK, Fischer MK, Tran VD, Tran MH.   +9 more
europepmc   +1 more source

Interleukin-8 Stimulates Human Immunodeficiency Virus Type 1 Replication and Is a Potential New Target for Antiretroviral Therapy

, 2001
Brian R. Lane, Karin Loré, Paul Bock, Jan Andersson, Michael Coffey, Robert M. Strieter, David M. Markovitz   +6 more
openalex   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma. [PDF]

Oncol Res
Anchondo GM, Parker K, Bruce A, Cortez E, Su LE.   +4 more
europepmc   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Activated immune infiltrates expand opportunities for targeted therapy in p53-abnormal endometrial carcinoma. [PDF]

J Pathol
Martin SD, Thornton S, Chow C, Milne K, de Barros JS, Morris KA, Leung S, Jamieson A, Nelson BH, Cochrane DR, Huntsman DG, Gilks CB, Hoang L, McAlpine JN, Zhang AW.   +14 more
europepmc   +1 more source