Results 381 to 390 of about 10,512,166 (412)
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Lasers in Surgery and Medicine, 2006
AbstractBackground and ObjectivesPhotodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies.Study Design/Materials and MethodsPDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target.
Nicolas Solban +2 more
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AbstractBackground and ObjectivesPhotodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies.Study Design/Materials and MethodsPDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target.
Nicolas Solban +2 more
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Targeted therapies in melanoma
Cancer Treatment Reviews, 2006In the last decade the incidence of melanoma has been rising. Despite this, survival remains substantially constant because early diagnosis of thin lesions has increased. By contrast, metastatic melanoma continues to have a poor prognosis and it still represents a challenge for oncologists. Response rates with single agent dacarbazine range from 10% to
Mirko Acquati, Paola Queirolo
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British Medical Bulletin, 1995
Melanin biosynthesis is limited to melanocytes partly as a consequence of transcriptional regulation of the enzymes involved in this pathway. Promoter sequences of these enzyme genes may be utilised to drive expression of complementary DNA coding for therapeutic genes so as to provide transcriptional targeting. We have used the 5'-flanking sequences of
R G Vile, I R Hart
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Melanin biosynthesis is limited to melanocytes partly as a consequence of transcriptional regulation of the enzymes involved in this pathway. Promoter sequences of these enzyme genes may be utilised to drive expression of complementary DNA coding for therapeutic genes so as to provide transcriptional targeting. We have used the 5'-flanking sequences of
R G Vile, I R Hart
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Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis.
Biochemical Society Transactions, 2020Targeting of estrogen receptor is commonly used as a first-line treatment for hormone-positive breast cancer patients, and is considered as a keystone of systemic cancer therapy. Likewise, HER2-targeted therapy significantly improved the survival of HER2-
S. Lev
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International Journal of Radiation Oncology*Biology*Physics, 2021
International ...
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Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers.
Cancer metastasis reviews, 2023Yu Wang, B. Deng
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Current Oncology Reports, 2014
The survival outcome of patients with malignant gliomas is still poor, despite advances in surgical techniques, radiation therapy and the development of novel chemotherapeutic agents. The heterogeneity of molecular alterations in signaling pathways involved in the pathogenesis of these tumors contributes significantly to their resistance to treatment ...
Mohamed Ali Hamza, Mark R. Gilbert
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The survival outcome of patients with malignant gliomas is still poor, despite advances in surgical techniques, radiation therapy and the development of novel chemotherapeutic agents. The heterogeneity of molecular alterations in signaling pathways involved in the pathogenesis of these tumors contributes significantly to their resistance to treatment ...
Mohamed Ali Hamza, Mark R. Gilbert
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Targeted Therapies in Mesothelioma
2019Malignant Pleural Mesothelioma (MPM) is an aggressive disease characterized by chemoresistance and few therapeutic options. First-line platinum-pemetrexed chemotherapy represents the current standard of care, and no indication is available for second-line treatments.
Loredana Urso, Giulia Pasello
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Nature Reviews Drug Discovery, 2010
Oncology has become one of the major focus areas for pharmaceutical and biotechnology companies. In 2009, ~16,000 of the ~40,000 Phase I, II and III trials listed on ClinicalTrials.gov were related to cancer (~40%). This large interest stems from the existence of high unmet need for improved treatments of multiple types of cancer and the substantial ...
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Oncology has become one of the major focus areas for pharmaceutical and biotechnology companies. In 2009, ~16,000 of the ~40,000 Phase I, II and III trials listed on ClinicalTrials.gov were related to cancer (~40%). This large interest stems from the existence of high unmet need for improved treatments of multiple types of cancer and the substantial ...
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Chemotherapy and Targeted Therapy
2016Salivary gland cancers are uncommon neoplasms of the head and neck that exhibit considerable pathological, biological, and clinical diversity, resulting in a paucity of prospective data regarding the use of non-surgical treatments. Chemotherapy has shown limited activity in patients with metastatic disease, and there has been little exploration of its ...
Mehmet Sen, Robin Prestwich
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