Results 391 to 400 of about 10,512,166 (412)
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Clinics in Dermatology, 2013
Since the discovery of activating mutations in the BRAF oncogene in melanoma, there has been remarkable progress in the development of targeted therapies for unresectable and metastatic melanoma. We review the latest developments in our understanding of the role of BRAF/MEK/ERK pathway signaling in melanoma, and the development of inhibitors of this ...
James S. Trimble +4 more
openaire +2 more sources
Since the discovery of activating mutations in the BRAF oncogene in melanoma, there has been remarkable progress in the development of targeted therapies for unresectable and metastatic melanoma. We review the latest developments in our understanding of the role of BRAF/MEK/ERK pathway signaling in melanoma, and the development of inhibitors of this ...
James S. Trimble +4 more
openaire +2 more sources
BioDrugs, 2010
Recent advances in understanding the biologic mechanisms underlying cancer development have driven the design of new therapeutic approaches, termed 'targeted therapies', that selectively interfere with molecules or pathways involved in tumor growth and progression.
Ciavarella S +3 more
openaire +4 more sources
Recent advances in understanding the biologic mechanisms underlying cancer development have driven the design of new therapeutic approaches, termed 'targeted therapies', that selectively interfere with molecules or pathways involved in tumor growth and progression.
Ciavarella S +3 more
openaire +4 more sources
Targeted therapy for osteosarcoma: a review
Journal of Cancer Research and Clinical Oncology, 2023Shizhe Li +3 more
semanticscholar +1 more source
Oncology Research and Treatment, 2016
The landscape of chronic lymphocytic leukemia (CLL) has undergone profound changes in the past years. First, the addition of CD20-targeting antibodies to conventional chemotherapy has improved the therapeutic outcome in the majority of CLL patients.
Kirsten Fischer +3 more
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The landscape of chronic lymphocytic leukemia (CLL) has undergone profound changes in the past years. First, the addition of CD20-targeting antibodies to conventional chemotherapy has improved the therapeutic outcome in the majority of CLL patients.
Kirsten Fischer +3 more
openaire +3 more sources
Diabetes Research and Clinical Practice, 1995
Non-insulin-dependent diabetes (NIDDM) is a common multimetabolic disorder with potential (and potentially severe) long-term complications affecting large and small blood vessels. Where microvascular complications (retinopathy, nephropathy and neuropathy) are concerned, the Diabetes Control and Complications Trial (DCCT), as well as much circumstantial
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Non-insulin-dependent diabetes (NIDDM) is a common multimetabolic disorder with potential (and potentially severe) long-term complications affecting large and small blood vessels. Where microvascular complications (retinopathy, nephropathy and neuropathy) are concerned, the Diabetes Control and Complications Trial (DCCT), as well as much circumstantial
openaire +3 more sources
Targeting complement in therapy
Immunological Reviews, 2001Summary:With increasing evidence that complement activation significantly contributes to the pathogenesis of a large number of inflammatory diseases, strategies that interfere with its deleterious action have become a major focus in pharmacological research. Endogenous soluble complement inhibitors (C1 inhibitor, recombinant soluble complement receptor
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Current trends of targeted therapy for oral squamous cell carcinoma
Journal of Cancer Research and Clinical Oncology, 2022Hongjiao Li +3 more
semanticscholar +1 more source
Targets for therapy in ependymoma
Targeted Oncology, 2011Ependymomas are among the rarest type of glioma and display significant heterogeneity based on patient age and tumor location. Treatment strategies include surgery and radiation, but the use of chemotherapy remains more controversial. Chemotherapy has been widely utilized in the pediatric population due to more aggressive disease in this cohort, and ...
openaire +3 more sources