Results 61 to 70 of about 2,445,408 (290)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Factors influencing task-shifting between rheumatologists and occupational therapists in hand osteoarthritis care: A qualitative study

Scandinavian Journal of Occupational Therapy
Background Task-shifting in healthcare aims to increase access to quality care, control healthcare expenditures and increase efficiency. However, studies suggest that the success of task-shifting initiatives vary and is context sensitive.Aim We aimed to ...
Silje Zink, Marte Feiring, Ingvild Kjeken   +2 more
doaj   +1 more source

Barriers and facilitators of child and guardian attendance in task-shifted mental health services in schools in western Kenya

Cambridge Prisms: Global Mental Health, 2020
BackgroundGlobally, nearly 140 million children have experienced the death of one or both parents, and as a result many experience higher rates of mental health problems.
Rosemary D. Meza, Sharon Kiche, Caroline Soi, Alya N. Khairuzzaman, Cristian J. Rivera Nales, Kathryn Whetten, Augustine I. Wasonga, Cyrilla Amanya, Shannon Dorsey   +8 more
doaj   +1 more source

Potential impact of task shifting on clinical labor costs.

, 2016
Potential impact of task shifting on clinical labor costs.
Dayanund Loykissoonlal (560278), Michel Tchuenche (3269754), Ananthy Thambinayagam (3154188), Vibhuti Haté (3269748), Emmanuel Njeuhmeli (194492), Steven Forsythe (194468), Eurica Palmer (3269757)   +6 more
core   +1 more source

Examples of task shifting in healthcare services delivery since COVID-19 pandemic.

, 2023
Examples of task shifting in healthcare services delivery since COVID-19 pandemic.
Shukanto Das (17604775), Genevie Fernandes (11453584), Liz Grant (4476529)   +2 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Factors perceived to influence implementation of task shifting in highly specialised healthcare: a theory-based qualitative approach

BMC Health Services Research, 2018
Background New approaches to control healthcare expenditures and increase access to quality care are required by decision-makers in high-income countries. One strategy is to reallocate tasks from doctors to nurses.
Eli Feiring, Astrid Eidesvik Lie
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Assessing planning and set-shifting abilities in autism: Are experimenter-administered and computerised versions of tasks equivalent? [PDF]

, 2013
The performance of individuals with autism spectrum disorder (ASD) on classic measures of executive functioning may suggest that people with this disorder are impaired only when tasks are administered by an experimenter, but not when the same tasks are ...
Williams, David M., David Williams, Williams, David, Jarrold, Christopher, Christopher Jarrold   +4 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source