Results 31 to 40 of about 157,713 (199)
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
A project management approach to long-term preservation of optical media tasks [PDF]
The Future of Information Sciences, 2015 Optical media used in common practice are rarely suitable for long-term preservation (LTP) tasks, they are more a mean of transmission of records between the producer of records and the organisation/archive (any archive in broader sense). Migration is a LTP method which can be used after the act of receiving records, but its dynamics may vary and it ...
openaire +2 more sources
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
Boundaries of photosynthesis: adaptations of carbon fixation in extreme environments
FEBS Open Bio, EarlyView.Photosynthesis faces challenges from environmental extremes of temperature, pH, and salinity, limiting gas diffusion, modifying membrane fluidity, and destabilizing photochemical and biochemical reactions. Photosynthetic organisms have evolved unique adaptations overcoming these stresses and maintaining their photosynthetic activity.
Pere Aguiló‐Nicolau +3 more
wiley +1 more source
Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies
Aging and Cancer, EarlyView.This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal +8 more
wiley +1 more source
Managing the Competencies of Team Members in Design Projects through Multi-period Task Assignment [PDF]
, 2010 Product design projects involve multiple team members with various knowledge and competencies that have to evolve with time, due to rapid organizational, technological and marketing changes. Project managers require management methods to optimize the assignment of tasks to human resources according to their competency levels and the need for competency
Hlaoittinun, Onanong +2 more
openaire +4 more sources
Aging and Cancer, EarlyView.ABSTRACT Purpose To assess the long‐term effects of a community cancer exercise program on quality of life, fatigue, weight, waist circumference, physical activity levels, lower extremity strength, body mass index (BMI), heart rate, and blood pressure, across non‐metastatic and metastatic patients.
Isaac Oppong, Roozbeh Naemi
wiley +1 more source
Crime Against History: Slavery, Race, and the 1776 Report
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT With the 2025 executive order, “Ending Radical Indoctrination in K‐12 Schooling,” the Trump administration reestablished the 1776 Commission, which produced The 1776 Report. This article argues that this report, which is an unsubtle response to The 1619 Project, reveals how White Christian Nationalists wish to mandate that a hyper‐patriotic ...
William V. Trollinger
wiley +1 more source