Results 81 to 90 of about 434,244 (289)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Research on Parallel Task Scheduling Algorithm of SaaS Platform Based on Dynamic Adaptive Particle Swarm Optimization in Cloud Service Environment

International Journal of Computational Intelligence Systems
To efficiently realize the parallel task scheduling of SaaS platform in large-scale cloud service environment, this paper studies the parallel task scheduling algorithm of SaaS platform based on dynamic adaptive particle swarm optimization in cloud ...
Jian Zhu, Qian Li, Shi Ying, Zhihua Zheng   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Deep Reinforcement Learning Task Scheduling Method for Real-Time Performance Awareness

IEEE Access
Load balancing is essential for the efficient delivery of cloud computing services, ensuring stable operation and robust performance under high load conditions.
Jinming Wang, Shaobo Li, Xingxing Zhang, Keyu Zhu, Cankun Xie, Fengbin Wu   +5 more
doaj   +1 more source

Pinwheel Scheduling for Fault-tolerant Broadcast Disks in Real-time Database Systems [PDF]

, 1996
The design of programs for broadcast disks which incorporate real-time and fault-tolerance requirements is considered. A generalized model for real-time fault-tolerant broadcast disks is defined.
Baruah, Sanjoy, Bestavros, Azer
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Hybrid static/dynamic scheduling for already optimized dense matrix factorization [PDF]

, 2011
We present the use of a hybrid static/dynamic scheduling strategy of the task dependency graph for direct methods used in dense numerical linear algebra. This strategy provides a balance of data locality, load balance, and low dequeue overhead.
Donfack, Simplice, Grigori, Laura, Gropp, William D., Kale, Vivek   +3 more
core   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A task container scheduling algorithm for spaceborne virtualization platform

Xibei Gongye Daxue Xuebao
With the help of lightweight virtualization technology such as containers, the spaceborne virtualization platform encapsulates computing tasks into containers to form task containers, so as to achieve efficient utilization of resources.
LIU Mingxuan, GUO Boyuan, LIU Xi, LIANG Xinxin, ZHAO Qianglong, YANG Xiaofeng, GU Jianhua   +6 more
doaj   +1 more source