Results 281 to 290 of about 315,874 (315)
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2019
Many proteins, particularly those that are intrinsically disordered and carry charges have a tendency to undergo liquid liquid phase separation (LLPS). Phase separation is a widespread mechanism by which cells concentrate a set of proteins to perform molecular reactions, and appear to compartmentalize molecular functions.
Kenneth S, Kosik, Songi, Han
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Many proteins, particularly those that are intrinsically disordered and carry charges have a tendency to undergo liquid liquid phase separation (LLPS). Phase separation is a widespread mechanism by which cells concentrate a set of proteins to perform molecular reactions, and appear to compartmentalize molecular functions.
Kenneth S, Kosik, Songi, Han
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Measurement of the Decays $\tau^- \to K^*$ $\nu_\tau$ and $\tau^- \to \rho^- \nu_\tau$
1988Using the ARGUS detector at DORIS II, we have determined the branching ratios for the decays τ−→K*−vτ and τ−→ρ−vτ to be (1.23 ±0.21−0.21+0.11)% and (21.5±0.4±1.9)%, respectively. These results are in agreement with theoretical expectations based on the standard model.
Albrecht, H. +80 more
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Science Translational Medicine
Nasal delivery of an oligomeric tau antibody loaded into micelles reduces pathology and ameliorates cognition in a mouse model of tauopathy.
Soraya Meftah +2 more
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Nasal delivery of an oligomeric tau antibody loaded into micelles reduces pathology and ameliorates cognition in a mouse model of tauopathy.
Soraya Meftah +2 more
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Histology and histopathology
Microtubule-associated protein tau is predominantly expressed in neurons in the form of multiple isoforms generated by alternative splicing. These isoforms differ in the presence of either three or four microtubule-binding repeats. These binding regions not only regulate tau's interaction with microtubules but are also critically involved in its ...
Indalo, Domene-Serrano +3 more
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Microtubule-associated protein tau is predominantly expressed in neurons in the form of multiple isoforms generated by alternative splicing. These isoforms differ in the presence of either three or four microtubule-binding repeats. These binding regions not only regulate tau's interaction with microtubules but are also critically involved in its ...
Indalo, Domene-Serrano +3 more
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2012
The protein tau is the most abundant microtubule associated protein in the central and peripheral nervous system. In the brain, tau plays a role in the assembly and stabilization of microtubules. The function of tau, however, appears to overlap with other microtubule binding proteins.
Nitin, Chaudhary, Ramakrishnan, Nagaraj
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The protein tau is the most abundant microtubule associated protein in the central and peripheral nervous system. In the brain, tau plays a role in the assembly and stabilization of microtubules. The function of tau, however, appears to overlap with other microtubule binding proteins.
Nitin, Chaudhary, Ramakrishnan, Nagaraj
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Science Signaling
The kinase TYK2 facilitates pathological tau assembly through protein-stabilizing modifications.
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The kinase TYK2 facilitates pathological tau assembly through protein-stabilizing modifications.
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2019
The pathological propagation of Tau protein is a hallmark of multiple neurodegenerative disorders, collectively referred to tauopathies with Alzheimer's disease (AD) being most prevalent, but including a range of frontotemporal dementias (FTDs). The extracellular Tau is important during the progression of tauopathies, although Tau is mainly expressed ...
Zhi, Ruan, Tsuneya, Ikezu
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The pathological propagation of Tau protein is a hallmark of multiple neurodegenerative disorders, collectively referred to tauopathies with Alzheimer's disease (AD) being most prevalent, but including a range of frontotemporal dementias (FTDs). The extracellular Tau is important during the progression of tauopathies, although Tau is mainly expressed ...
Zhi, Ruan, Tsuneya, Ikezu
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Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
Cell, 2022Tara E Tracy +2 more
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