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More on Taurine

Pediatrics, 1989
In a recent commentary, Perlman called for further study of the effects of taurine and expressed reservations about our randomized trial of taurine supplementation for infants weighing ≤1300 g at birth. We agree with the need for further investigation but would like to respond to his criticism that our sampling of patients was biased and that our ...
J E, Tyson, C, Mize, R, Lasky
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Taurine in development

Physiological Reviews, 1988
Taurine is a ubiquitous dietary constituent of most mammals and is present in especially high concentrations in the tissues of developing mammals. Research to date indicates that taurine plays an important role in the development of the nervous system and the process of migration in particular.
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Taurine, Taurine Analogues, and Mitochondrial Function and Dysfuntion

2006
It has become apparent in recent years that mitochondria are integrally involved in the mechanism of both apoptosis and necrosis (Ankarcrona et al., 1996; Tatton et al., 1999; Finkel et al., 2001). Mitochondria possess a latent mechanism, called the permeability transition pore (PTP), that when activated will open and allow the efflux of components ...
PALMI, MITRI   +3 more
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Taurine and epilepsy

Epilepsy Research, 2013
Dysfunction of excitatory and inhibitory neurotransmitters or neuromodulators is thought to underlie epileptic symptoms. Taurine, 2-aminoethanesulfonate, is a ubiquitous free amino acid abounding in the brain of humans and most animal species. It hyperpolarizes neurons and inhibits their firing.
Simo S, Oja, Pirjo, Saransaari
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Taurine and Kynureninase

1996
Kynureninase is the most important enzyme in tryptophan metabolism. In the main pathway of tryptophan metabolism, kynureninase forms 3-OH-anthranilic acid from 3-OH-kynurenine. In this reaction vitamin B6 is a co-enzyme. An important relationship between -SH groups and liver kynureninase apoenzyme has been reported by Takeuchi8, 9 and Izuta1.
Y, Shibata   +9 more
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Taurine inhibits osteoclastogenesis through the taurine transporter

Amino Acids, 2009
Several studies have suggested a direct link between taurine and bone homeostasis. However, the mechanisms of taurine on the regulation of bone metabolism have not been elucidated. Using a coculture of osteoblasts and bone marrow cells as a model for the study of osteoclastogenesis, RANKL-stimulated RAW264.7 cells and M-CSF- and RANKL-induced bone ...
Ling-Qing, Yuan   +9 more
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Glutamyl‐Taurine Is the Predominant Synaptic Taurine Peptide

Journal of Neurochemistry, 1985
Abstract: Several taurine‐containing peptides have been identified from trichloracetic acid extracts of synaptosomes and their subcellular vesicles prepared from calf brain. These peptides contain aspartic and glutamic acids, serine and taurine, and are often present in an N‐acetylated form. The peptides were isolated as single spots by TLC.
K M, Marnela   +4 more
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Killing of Schistosomula by Taurine Chloramine and Taurine Bromamine

The American Journal of Tropical Medicine and Hygiene, 1987
Eosinophils generate hypochlorous acid when stimulated with opsonized particles. The hypochlorous acid can react with beta-amino acids such as taurine to produce chloramines with a long lifetime. In the presence of bromide, eosinophils generate hypobromous acid which can react with taurine to generate taurine bromamine. As taurine is abundantly present
M, Yazdanbakhsh, C M, Eckmann, D, Roos
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Taurine and atherosclerosis

Amino Acids, 2012
Taurine is abundantly present in most mammalian tissues and plays a role in many important physiological functions. Atherosclerosis is the underlying mechanism of cardiovascular disease including myocardial infarctions, strokes and peripheral artery disease and remains a major cause of morbidity and mortality worldwide.
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Taurine and the Premature

Biology of the Neonate, 2009
In the human fetus and in the early postnatal period, during development, the total body taurine content, particularly of the brain, increases markedly. It can be estimated that the human fetus accumulates approximately 50–60 μmol/24 h during the last 4 weeks of pregnancy. As there is evidence for the relative inability of infants to synthesize taurine,
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