Results 281 to 290 of about 2,026,427 (351)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

open access: yesFEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source
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Coupling of taxonomic diversity and morphological disparity in Devonian trilobites?

Historical Biology, 2023
Morphological disparity and taxonomic richness are two major aspects of evolution used to understand biodiversity changes. These metrics are often decoupled in time, particularly during the early history of clades.
Valentin Bault, C. Crônier, C. Monnet
semanticscholar   +1 more source

A unifying framework for analyzing temporal changes in functional and taxonomic diversity along disturbance gradients.

Ecology, 2021
Frameworks exclusively considering functional diversity are gaining popularity, as they complement and extend the information provided by taxonomic diversity metrics, particularly in response to disturbance.
Erin I. Larson   +6 more
semanticscholar   +1 more source

Dynamics of taxonomic diversity

Paleobiology, 1980
A general model of taxonomic diversity, incorporating diversity-dependent rates of origination and extinction, is constructed to examine the dynamic responses of diversity to perturbation. The model predicts that the trajectories of diversification increase and decrease are substantially different.
Timothy R. Carr, Jennifer A. Kitchell
openaire   +1 more source

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