Results 111 to 120 of about 173,934 (294)

Multiple facets of stream macroinvertebrate alpha diversity are driven by different ecological factors across an extensive altitudinal gradient

open access: yesEcology and Evolution, 2019
Environmental filtering and spatial structuring are important ecological processes for the generation and maintenance of biodiversity. However, the relative importance of these ecological drivers for multiple facets of diversity is still poorly ...
Zhengfei Li   +5 more
doaj   +1 more source

Using abundance data to assess the relative role of sampling biases and evolutionary radiations in Upper Muschelkalk ammonoids [PDF]

open access: yes, 2011
The Middle Triassic ammonoid genus Ceratites diversified spectacularly within the Germanic Muschelkalk Basin during the Anisian/Ladian (244–232 Mya). Previous studies have interpreted this diversification as a sequence of rapid, endemic radiations from a
Kiessling, Wolfgang   +1 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Understanding drivers of species distribution change: a trait-based approach [PDF]

open access: yes, 2013
The impacts of anthropogenic environmental change on biodiversity are well documented, with threats such as habitat loss and climate change identified as causes of change in species distributions.
Powney, Gary, Powney, Gary
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Assessment of the influence of intrinsic environmental and geographical factors on the bacterial ecology of pit latrines [PDF]

open access: yes, 2016
Funding Information: This research received financial support from the Bill and Melinda Gates Foundation (grant number OPP52641). AWW and JP were supported by the Wellcome Trust [grant number 098051]. AWW and the Rowett Institute of Nutrition and Health,
Abdelahi, Faraji   +10 more
core   +4 more sources

Climatic and Catchment-Scale Predictors of Chinese Stream Insect Richness Differ between Taxonomic Groups

open access: yesPLOS ONE, 2015
Little work has been done on large-scale patterns of stream insect richness in China. We explored the influence of climatic and catchment-scale factors on stream insect (Ephemeroptera, Plecoptera, Trichoptera; EPT) richness across mid-latitude China. We assessed the predictive ability of climatic, catchment land cover and physical structure variables ...
Tonkin, Jonathan D.   +6 more
openaire   +6 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Quantifying the relative importance of climate and habitat on structuring the species and taxonomic diversity of aquatic plants in a biodiversity hotspot of tropical Asia [PDF]

open access: yes, 2002
It has not been well known how climate and habitat variables will influence the distribution of plant species to some extents at mesoscales. In this report, by using the distribution of aquatic plants in Western Ghats, a biodiversity hotspot in tropical ...
Marcelo Fagioli   +3 more
core   +5 more sources

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