Results 131 to 140 of about 398,272 (314)
Advanced Science, EarlyView.This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley +1 more source
Advanced Science, EarlyView.P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang +8 more
wiley +1 more source
SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition
Advanced Science, EarlyView.Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo +14 more
wiley +1 more source
Vertical Integration and Internet Industry Structure: An Application of the Pricing Taxonomy [PDF]
, 1997 This paper utilizes the Internet Pricing Interface Taxonomy to examine incentives of service providers at various stages in the service provider value chain to vertically integrate.
William Lehr, Lehr, William
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Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression
Advanced Science, EarlyView.The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren +20 more
wiley +1 more source
Abstract This chapter provides a critical discussion of the taxonomies that are commonly applied to corporate law and governance. It starts with a presentation of four types of typologies: limited typologies dealing with either legal or non-legal questions, and general typologies having either a legal or a non-legal focus.
openaire +2 more sources
Capacity building in taxonomy and systematics [PDF]
, 2009 Needs-driven capacity building is required as a matter of urgency to overcome the present lack of taxonomists and systematists who are skilled in natural history and collections.
Figueiredo, Estrela +1 more
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Advanced Science, EarlyView.Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu +8 more
wiley +1 more source
Developing a taxonomy for the understanding of business and it alignment paradigms and tools
, 2008 The alignment of information technology with business objectives tends to be a managerial priority in modern organisations. Thus, practitioners and researchers have proposed different approaches to assess this relationship, some following similar ...
Orozco, J, Gutierrez, A, Serrano, A
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