Results 11 to 20 of about 5,757 (204)

Vegfr3 and Tbx1 Interact in Cardiac Morphogenesis [PDF]

Journal of Cardiovascular Development and Disease
Gene inactivation in model organisms has identified numerous genes and signaling pathways involved in mammalian cardiac outflow tract (OFT) development.
Stefania Martucciello, Marchesa Bilio, Sara Cioffi, Ilaria Aurigemma, Mariangela Cavallaro, Antonio Baldini, Elizabeth Illingworth   +6 more
doaj   +3 more sources

Defective Vagal Innervation in Murine Tbx1 Mutant Hearts [PDF]

Journal of Cardiovascular Development and Disease, 2018
Haploinsufficiency of the T-box transcription factor TBX1 is responsible for many features of 22q11.2 deletion syndrome. Tbx1 is expressed dynamically in the pharyngeal apparatus during mouse development and Tbx1 homozygous mutants display numerous ...
Amélie Calmont, Naomi Anderson, Jenifer P. Suntharalingham, Richard Ang, Andrew Tinker, Peter J. Scambler   +5 more
doaj   +9 more sources

Tbx1 is a negative modulator of Mef2c [PDF]

Human Molecular Genetics, 2011
The developmental role of the T-box transcription factor Tbx1 is exquisitely dosage-sensitive. In this study, we performed a microarray-based transcriptome analysis of E9.5 embryo tissues across a previously generated Tbx1 mouse allelic series.
Zhen Zhang, Rosa Ferrentino, L. S. Pane, Luisa Cutillo, Z. Zhang, T. Huynh, Pane L. S, CUTILLO, Luisa, BALDINI, ANTONIO, Tuong Huynh4, L. Cutillo, Zhang Z, Baldini A., Antonio Baldini, Luna Simona Pane, R. Ferrentino, Ferrentino R, Tuong Huynh   +17 more
core   +6 more sources

TBX1 is required for inner ear morphogenesis. [PDF]

Human Molecular Genetics, 2003
TBX1 is thought to be a critical gene in the pathogenesis of del22q11/DiGeorge syndrome (DGS). Morphological abnormalities of the external ear and hearing impairment (conductive or sensorineural) affect the majority of patients.
E. Lindsay, MORISHIMA M, VITELLI F, LINDSAY E.A., ILLINGWORTH, ELISABETH ANNE, T. Pramparo, A. Viola, BALDINI, ANTONIO, F. Vitelli, BALDINI A, VIOLA A, M. Morishima, PRAMPARO T   +12 more
core   +6 more sources

Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo

Molecular Metabolism, 2020
Objective: T-box 1 (TBX1) has been identified as a genetic marker of beige adipose tissue. TBX1 is a mesodermal development transcription factor essential for tissue patterning and cell fate determination.
Matthew J Potthoff, Sheps King-Mcalpin, Kathleen Markan   +2 more
exaly   +3 more sources

Tbx1: Transcriptional and Developmental Functions

Current topics in developmental biology, 2017
Recent data have paved the way to mechanistic studies into the role of Tbx1 during development. Tbx1 is haploinsufficient and is involved in an important genetic disorder. The gene encodes a T-box transcription factor that is expressed from approximately
F.G. Fulcoli, Baldini, A., A. Baldini, ILLINGWORTH, ELISABETH ANNE, E. Illingworth, Fulcoli, F. G., Illingworth, E.   +6 more
core   +5 more sources

"Mechanisms of transcriptional regulation by Tbx1" [PDF]

, 2010
Deletion 22q11.2 syndrome (22q11DS) is the most common microdeletion syndrome in man, with an incidence of approximately 1:4000 live births (1); the major malformations include congenital heart defects such as truncus arteriosus (TA) and interrupted ...
Pane, Luna Simona
core   +4 more sources

Epigenetic silencing of TBX1 inactivates the Hippo pathway to potentiate chemoresistance in esophageal squamous cell carcinoma [PDF]

Cell Death and Disease
Neoadjuvant chemotherapy (NAC) is a key component of the standard treatment regimen for patients with advanced esophageal squamous cell carcinoma (ESCC); however, a substantial proportion of patients fail to benefit from NAC because of intrinsic or ...
Zhong Xu, Gang Ma, Ying Shen, Li Tan, Xuejuan Sun, Lei Peng, Weiyan Peng, Lin Ye   +7 more
doaj   +2 more sources

Tbx1 heterozygosity in the oligodendrocyte lineage shifts myelinated axon composition in the mouse fimbria without behavioral impairments [PDF]

Molecular Brain
Constitutive heterozygosity of Tbx1, a T-box transcription factor gene located within the 22q11.2 deletion region, results in behavioral deficits and altered composition of myelinated axons in the fimbria, together with reduced levels of an ...
Anne Marie Wells, Takaki Tanifuji, Takeshi Takano, Arumu Endo, Gina Kang, Marisa Esparza, Qian Shi, Manzoor A. Bhat, Noboru Hiroi   +8 more
doaj   +2 more sources

From a developmental atlas to maps of disease origin. [PDF]

Clin Transl Med
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Pan J, Lin Z, Feng J, Zhang G, Fu Z, Huang H, Ding G.   +6 more
europepmc   +2 more sources