Results 191 to 200 of about 8,343 (220)

Tbx1 antagonizes thymus organogenesis (86.4)

The Journal of Immunology, 2009
Abstract The thymus and parathyroids originate from organ-specific domains in endoderm of the 3rd pharyngeal pouch (PP), identified by Foxn1 and Gcm2 expression respectively at embryonic day 11 (E11). The molecular mechanisms regulating fate determination in the 3rd PP are not clear.
Kim T Cardenas, Zhijie Liu, Micheline Laurent, Carla Carter, Nancy Manley, Ellen Richie   +5 more
openaire   +1 more source

Dissecting contiguous gene defects: TBX1

Current Opinion in Genetics & Development, 2005
DiGeorge syndrome is mainly caused by a multigene, heterozygous, interstitial chromosomal deletion. Of the approximately 30 deleted genes, Tbx1 is the only gene that, after an extensive functional analysis in the mouse, has been found to be haploinsufficient.
openaire   +5 more sources

Phenotypic variability of atypical 22q11.2 deletions not includingTBX1

American Journal of Medical Genetics Part A, 2012
AbstractInterstitial deletions of the chromosome 22q11.2 region are the most common microdeletions in humans. TheTBX1gene is considered to be the major candidate gene for the main features in 22q11.2 deletion syndrome, including congenital heart malformations, (para)thyroid hypoplasia, and craniofacial abnormalities.
Verhagen, Judith, Diderich, Karin, Oudesluijs, Grietje, Verheijen - Mancini, Grazia, Eggink, Alex, Verkleij-Hagoort, AC, Groenenberg, Irene, Willems, PJ, Plessis, Frederik, Man, Stella, Srebniak, Gosia, Opstal, D, Hulsman, Lorette, van Zutven, Laura, Wessels, Marja   +14 more
openaire   +3 more sources

TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis

Journal of Dental Research, 2020
The synchondrosis in the cranial base is an important growth center for the craniofacial region. Abnormalities in the synchondroses affect the development of adjacent regions, including the craniofacial skeleton. Here, we report that the transcription factor TBX1, the candidate gene for DiGeorge syndrome, is expressed in mesoderm-derived chondrocytes ...
N. Funato, D. Srivastava, S. Shibata, H. Yanagisawa   +3 more
openaire   +2 more sources

Tbx1, subpulmonary myocardium and conotruncal congenital heart defects

Birth Defects Research Part A: Clinical and Molecular Teratology, 2011
AbstractConotruncal congenital heart defects, including defects in septation and alignment of the ventricular outlets, account for approximately a third of all congenital heart defects. Failure of the left ventricle to obtain an independent outlet results in incomplete separation of systemic and pulmonary circulation at birth.
Pauline Parisot, Karim Mesbah, Magali The´veniau–Ruissy, and Robert G. Kelly   +3 more
openaire   +2 more sources

Lymphatic expression of TBX1 helps to heal the heart

Nature Reviews Immunology, 2023
openaire   +2 more sources

TBX1 regulates myogenic differentiation by activating the TGFβ-Smad2/3 pathway in myoblasts

Experimental Biology and Medicine, 2023
Yu Zhang
exaly  

The role of TBX1 in the developing secondary palate

British Journal of Oral and Maxillofacial Surgery, 2013
Stephanie Bryan, M. Zoupa, G.M. Xavier, M. Arno, M.T. Cobourne   +4 more
openaire   +1 more source

22q11 Deletion Syndrome: A Role for TBX1 in Pharyngeal and Cardiovascular Development

Pediatric Cardiology, 2010
Peter J Scambler
exaly  

The del22q11.2 Candidate Gene Tbx1 Controls Regional Outflow Tract Identity and Coronary Artery Patterning

Circulation Research, 2008
Magali Théveniau-Ruissy, Karim Mesbah, Marie‐Geneviève Mattei   +2 more
exaly