Results 151 to 160 of about 256,128 (247)

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

The Impact of Canada's Working Income Tax Benefit on the Labor Supply of Low‐Income Workers

Industrial Relations: A Journal of Economy and Society, EarlyView.
ABSTRACT We use administrative tax data to estimate the effect of the Working Income Tax Benefit (WITB) on the labor supply of single, low‐income workers in Canada. Our analytical approach exploits low knowledge of the program, which generates variation in the benefit receipt both between and within eligible tax filers over time.
Kourtney Koebel, Dionne Pohler
wiley   +1 more source

Membranes for Periodontal and Bone Regeneration: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This paper presents and highlights a summary of the past, present, and future of membranes for oral regeneration in clinical applications and fundamental studies. ABSTRACT Implant dentistry and periodontology have shown an increasing demand for regenerative procedures associated with biomaterials targeting successful clinical outcomes and predictable ...
Marcel F. Kunrath, Gabriel L. Magrin, Candida S. Zorzo, Ingrid Rigotto, Hanna Aludden, Christer Dahlin   +5 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

30 Years of Enamel Matrix Derivative (EMD): Biological Foundations and Systematic Review With Meta‐Analyses Across Multiple Clinical Indications

Journal of Periodontal Research, EarlyView.
EMD is one of the few biological agents with human histologic evidence supporting periodontal regeneration. This is reflected in improved clinical outcomes when used in regenerative surgery for intrabony defects. Despite its biological plausibility for broader therapeutic applications, further high‐quality randomized clinical trials are needed to ...
Richard J. Miron, Nima Farshidfar, Yu‐Kang Tu, Chian‐Heng Su, Paras Ahmad, Nathan E. Estrin, Reinhard Gruber, Yoshinori Shirakata, Dieter D. Bosshardt, Mario Romandini, Anton Sculean   +10 more
wiley   +1 more source

Impact of Demographic Modifiers on Readability of Myopia Education Materials Generated by Large Language Models

Clinical Ophthalmology
Gabriela G Lee, Deniz Goodman, Ta Chen Peter Chang Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USACorrespondence: Ta Chen Peter Chang, Department of Ophthalmology, Bascom Palmer Eye ...
Lee GG, Goodman D, Chang TCP
doaj  

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

What Are the Optimal Sagittal Alignments in Primary Total Knee Arthroplasty: A Systematic Review and Meta‐Analysis

Orthopaedic Surgery, EarlyView.
The optimal sagittal alignment targets for TKA remain uncertain; however, favorable sagittal alignments are hypothesized to improve prognosis and function. Discussions on sagittal alignments emphasize biomechanical, anatomical, and soft tissue‐friendly approaches to surgery.
Guoqing Li, Yong Huang, Wang Deng, Ji Zhang   +3 more
wiley   +1 more source