Results 61 to 70 of about 37,808 (265)

Versatile Detection of Cellular Protein via Fluorescence Anisotropy

Advanced Science, EarlyView.
Cell Lysate Fluorescence Anisotropy (CFAST) utilizes long lifetime dye‐labeled nanobodies for rapid protein quantification in minimally purified, complex cell lysate. When coupled with cellular thermal shift, CFAST allows high‐throughput detection of endogenous protein‐small molecule engagement, facilitating the discovery of novel binders for ...
Qing Tang, Yuan‐Ping Wei, Ricky Ruiqi Ma, Na Wei, Tammy Zihan Zhou, Hilary Kung‐Yu Ho, Zafar Iqbal Bhat, Iqra Ishrat, Xiaoyu Li, Judy Wai Ping Yam, Yung Hou Wong, Qiankun Wang, Justin L. Tan   +12 more
wiley   +1 more source

Non‐Equilibrium Synthesis of Whitlockite Assisted by Localized H2O Vapor Pressure

Advanced Science, EarlyView.
A carbon substrate acts as a microheater during intense pulsed light irradiation, enabling rapid heating and cooling for whitlockite formation. In contrast to conventional white ceramic synthesis with weak photothermal response, this platform concentrates thermal energy locally and promotes phase‐selective crystallization under ultrafast ...
Min‐Jung Kim, Minwoo Lee, In‐Ho Jung, Seung‐Kyun Kang, Ji‐Soo Jang, Hyung‐Seop Han   +5 more
wiley   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Documentos

Aportes para la Integración Latinoamericana
• MERCADO COMUN DEL SUR (MERCOSUR) 1) LXIV CUMBRE: Comunicado conjunto de los Presidentes de los Estados Partes del MERCOSUR y Bolivia. (8 de julio de 2024) Asunción 2) Declaración presidencial de lucha contra el Crimen Organizado Transnacional (COT).
MERCOSUR ALBA-TCP
doaj   +2 more sources

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

Consideraciones metodológicas para la investigación con simuladores de red

Informes Científicos y Técnicos (Universidad Nacional de la Patagonia Austral), 2019
La simulación permite recrear escenarios para su estudio, mediante programas de computadora, sin necesidad de implementarlos en el mundo real. Esto reduce el costo de experimentación e incrementa el nivel de control que se tiene sobre un modelo de ...
Franco Trinidad, Carlos Talay
doaj   +1 more source

D–A Type Perylene Micelles With Synergistic Charge/Energy Transfer for Dual‐Path ROS Generation and Enhanced Photocatalysis

Advanced Science, EarlyView.
Dual‐state activation of singlet and triplet excitons is achieved in perylene‐based nanomicelles via donor engineering. By synergistically pairing charge transfer with energy transfer pathways, while concurrently enabling pollutant pre‐enrichment, this strategy establishes spatial coupling between efficient ROS generation and rapid mineralization ...
Chenfan Xie, Jin Gao, Guan Wang, Xinyue Huang, Xinyi Hu, Lijun Zhu, Liujun Yang, Hua Li, Jianmei Lu   +8 more
wiley   +1 more source

Test derivation based on tree FSMs and tree automata

Труды Института системного программирования РАН, 2018
In this paper, an approach for testing software implementations of telecommunication protocols based on tree finite state machines (FSM) is proposed. The first step is the extraction of the specification Extended FSM from an informal protocol description.
Maria Forostyanova
doaj   +1 more source

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

Advanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng, Evan M. Cale, Amirabbas Maghsoudi, Matthew S. Sutton, Nancy S. Longo, Rebecca A. Gillespie, Lingshu Wang, Ivan Kosik, Sue Chong, Atsuhiro Yasuhara, Tatsiana Bylund, Arne Schön, Prabhanshu Tripathi, Yaroslav Tsybovsky, Haotian Lei, Nicholas C. Morano, Allison B. Lupatkin, Abraham J. Morton, Zabrina C. Lang, Jordan E. Becker, Isabella R. Frascilla, Myungjin Lee, Ning Li, Cuiping Liu, Ryan S. Roark, Chen‐Hsiang Shen, I‐Ting Teng, David J. Van Wazer, Danyi Wang, Lingyuan Wu, Goran Ahlsen, Mike Castro, Haijuan Du, Michael J. Ernandes, Tiansheng Li, Bob C. Lin, Mark K. Louder, Krisha McKee, Jonah S. Merriam, Sijy O'Dell, Li Ou, Sergei Pletnev, David Prikryl, Qi Qiu, Sarah Rubin, Mallika Sastry, Stephen D. Schmidt, Asif Shajahan, Andrea R. Shiakolas, Sanjay Srivatsan, Baoshan Zhang, Qiong Zhou, Mark Connors, Jason G. Gall, Yicheng Guo, Rick K. Huang, Yaoxing Huang, Richard A. Koup, Q. Paula Lei, John R. Mascola, Reda Rawi, Leonid Serebryannyy, Lawrence Shapiro, Zizhang Sheng, David D. Ho, Patrick C. Wilson, Jonathan W. Yewdell, Theodore C. Pierson, Masaru Kanekiyo, Nicole A. Doria‐Rose, Peter D. Kwong, Tongqing Zhou   +71 more
wiley   +1 more source