Results 141 to 150 of about 190,504 (245)

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

WCN25-3856 BIZARRE CLINICAL PRESENTATIONS OF DISORDERS OF COMPLEMENT DYSREGULATION – CASE SERIES

Kidney International Reports
Mithun Abraham Santhosh, GOMATHY S, NOBLE GRACIOUS, DEVI S SRUTHI, PRADEEP B   +4 more
doaj   +1 more source

Functional brain network organization during the 40-Hz auditory steady-state response in children with and without autism spectrum disorder. [PDF]

Front Psychiatry
Yasumoto M, Miyagishi Y, Hirosawa T, Ono Y, Soma D, Osaka Y, Kameya M, Yuasa K, Sano M, Takeuchi R, Niu Y, Yoshimura Y, Shiota Y, Tanaka S, Hasegawa C, Kikuchi M.   +15 more
europepmc   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

DARIP Technique: A Novel Approach in the Surgical Management of Placenta Accreta Spectrum in the Second Trimester From Tu Du Hospital, Vietnam

Case Reports in Obstetrics and Gynecology
Ngoc Hai Tran, Phuc Nhon Nguyen, Van Hoang Bui   +2 more
doaj   +1 more source

The developmental shift in aperiodic activity and its link to the default mode network in attention-deficit hyperactivity disorder. [PDF]

Psychol Med
Li H, Wu GS, Zhu Y, Dang C, Zhong SG, Zhao XX, Luo XS, Wang YF, Sun L.   +8 more
europepmc   +1 more source

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Effects of monoglucosyl hesperidin on human lymphatic circulatory function: A randomized placebo-controlled, double-blind, crossover trial. [PDF]

Sci Rep
Shinaoka A, Honjo T, Takata K, Karasudani Y, Moriguchi S, Tanaka Y, Minami H, Maekawa T, Maeda A, Kimata Y.   +9 more
europepmc   +1 more source

Dumbbell‐Structured Plasmonic‐Enhanced Optical Nanoprobes Boosting Photo‐Magnetic‐Acoustic Multimodal Imaging‐Guided Photodynamic‐Photothermal Synergistic Treatment and Immunogenic Death in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study reports a novel rationally‐designed optical nanoprobe based on dumbbell‐shaped mesoporous silica‐coated gold nanorods, loaded with rare‐earth oxides, photosensitizers, and tumor‐targeted peptides, enabling plasmonic‐enhanced multimodal imaging and PTT‐PDT synergy.
Baikang Zhuang, Yubiao Yang, Wen Han, Yi Tang, Chengxin Yao, Fuli Zhao, Wenxiao Fang, Jinjie Li, Xiaolan Huo, Yiqian An, Yuanzhi Shao, Botao Gao, Jinchang Yin   +12 more
wiley   +1 more source

A Novel Nitrogen Metabolism Pathway in Strain <i>Gordonia</i> sp. TD-46: Genomic and Enzymatic Evidence. [PDF]

Biology (Basel)
Zheng P, Li H, Yan X, Ao D, Yue W, Zhang S, Yang G, Cai Z.   +7 more
europepmc   +1 more source