Results 61 to 70 of about 287,658 (289)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

IMPROVEMENT OF QUALITY OF THE BRIQUETTED FERROSILICIUM

Литьë и металлургия, 2013
IMPROVEMENT OF QUALITY OF THE BRIQUETTED ...
A. G. Georgadze, M. I. Elashvili, A. N. Pletnev, P. A. Nikiforov   +3 more
doaj  

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Development of TD Website and Repository [PDF]

, 2017
SEAFDEC, an Inter-Governmental Organization plays an important role in promotion of sustainable development of fisheries and aquaculture in the Southeast Asian Region for more than four decades.
Imsamrarn, Namfon
core  

SOME ECONOMIC INCENTIVES AT USING OF THE WORKED OVER WASTE PRODUCTS IN METALLURGICAL PRODUCTION

Литьë и металлургия, 2013
The statistical analysis of the production of certain metallurgical enterprises of Urals and Siberia on waste formation and their secondary application is carried out.
S. A. Nikiforov, M. V. Nikiforova, V. I. Gerner, A. N. Georgadze, M. I. Elashvili, V. V. Obrezkov, A. N. Pletnev   +6 more
doaj  

Adverse drug reactions seen in cancer patients undergoing palliative care treatment at a palliative care center in Alappuzha

National Journal of Physiology, Pharmacy and Pharmacology
Background: Adverse drug reactions are a major contributor to morbidity and hospitalization in patients and have been held responsible for as much as 5% of hospital admissions.
Anand Alex, Sai Nathan R, Deepa George
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Geographical variation in the clinical presentation of endomyocardial fibrosis in India?

Indian Heart Journal, 2018
Objectives: To compare the clinical presentation, clinical profile and survival of two groups of endomyocardial fibrosis patients. Methods: The study was a prospective cohort study, or a prospective case series, comparing all consecutive ...
Prabha Nini Gupta, Subair M. Kunju, Baiju Rajan, A. George Koshy, Sunitha Vishwanathan, Preeti Sara George, Praveen Velappan   +6 more
doaj   +1 more source

An observational study on the effectiveness of tolvaptan in patients with euvolemic and hypervolemic hyponatremia admitted to a tertiary care center

National Journal of Physiology, Pharmacy and Pharmacology, 2023
Background: Hyponatremia is a common electrolyte abnormality encountered in hospital wards. Even mild hyponatremia can result in significant morbidity and mortality especially in elderly.
Scaria Pulikkunnel Thomas, Udayamma Kalthattunkal Parvathi, Jitha Sushama   +2 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source