Results 151 to 160 of about 44,270 (261)

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Pharmacological and Mechanistic Interventions for Cognitive Impairment Associated With Schizophrenia: A Review of Registered Clinical Trials

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 402-431, May 2026.
ABSTRACT Background Schizophrenia is characterized by positive, negative, and cognitive symptoms. Current pharmacological treatments often fail to address cognitive deficits. In this review of clinical trials, we aim to identify studies that explore neurobiological (non‐psychological) strategies to address Cognitive Impairment Associated with ...
Bahareh Peyrovian, Lena Palaniyappan, Theodore T. Kolivakis, Howard C. Margolese   +3 more
wiley   +1 more source

Predicting Response to Pro‐Cognitive Interventions in Mood Disorders: A Systematic Review by the International Society for Bipolar Disorders Targeting Cognition Task Force

Acta Psychiatrica Scandinavica, Volume 153, Issue 5, Page 374-401, May 2026.
ABSTRACT Introduction Major depressive disorder (MDD) and bipolar disorder (BD) are often associated with persistent cognitive deficits that impair psychosocial functioning. While pro‐cognitive interventions show promise, trial findings are inconsistent, potentially due to baseline factors influencing treatment response.
Dimosthenis Tsapekos, Michail Kalfas, Johanna M. Schandorff, Caterina del Mar Bonnin, Christopher R. Bowie, Vicent Balanzá‐Martínez, Katherine E. Burdick, Andre F. Carvalho, Annemieke Dols, Katie Douglas, Peter Gallagher, Gregor Hasler, Lars V. Kessing, Hanne L. Kjærstad, Beny Lafer, Kathryn E. Lewandowski, Carlos López‐Jaramillo, Anabel Martinez‐Aran, Roger S. McIntyre, Richard J. Porter, Scot E. Purdon, Ayal Schaffer, Paul R. A. Stokes, Tomiki Sumiyoshi, Ivan J. Torres, Tamsyn E. Van Rheenen, Lakshmi N. Yatham, Jeff Zarp, Allan H. Young, Eduard Vieta, Kamilla W. Miskowiak   +30 more
wiley   +1 more source

rTMS Suppresses Tobacco Craving via Enhanced Prefronto‐Striato‐Thalamic Connectivity

Addiction Biology, Volume 31, Issue 5, May 2026.
This study aimed to investigate the therapeutic effects of rTMS on tobacco use disorder (TUD). The findings demonstrated that participants with TUD exhibited reduced cigarette cravings following treatment, accompanied by a reorganization of the prefrontal–striatal pathway and enhanced top‐down cognitive control.
Xin Luo, Xuefeng Ma, Shuang Li, Hong'an Chen, Bo Yang, Yanbin Zheng, Guang‐Heng Dong   +6 more
wiley   +1 more source

Huntington's Disease‐like Syndrome as a Rare Presentation of CACNA1A‐Related Disorder

Movement Disorders Clinical Practice, Volume 13, Issue 5, Page 1322-1325, May 2026.
Petros Boumis, Constantin Potagas, Christos Koros, Vasilios Constantinides, Nikolaos Ragazos, Chrysoula Koniari, Stavroula Aristeidou, Chrisoula Kartanou, Emmanouela Linardaki, Nektarios Tavernarakis, Evangelos Anagnostou, Leonidas Stefanis, Socratis Papageorgiou, Georgia Karadima, Georgios Koutsis   +14 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Transcranial direct current stimulation of the dorsolateral prefrontal cortex improves dual-task performance in people with stroke. [PDF]

J Neuroeng Rehabil
Li S, Chen P, Qin Y, Wong TWL, Ng SSM.
europepmc   +1 more source

Opsoclonus‐Myoclonus‐Ataxia Syndrome Associated with Coexisting Anti‐N‐Methyl‐D‐Aspartate Receptor and Glial Fibrillary Acidic Protein Antibodies

Movement Disorders Clinical Practice, Volume 13, Issue 5, Page 1313-1317, May 2026.
Eriko Igami, Yutaka Oji, Akihiro Yamaguchi, Shin‐ichi Ueno, Yuji Tomizawa, Taiji Tsunemi, Taku Hatano, Nobutaka Hattori   +7 more
wiley   +1 more source

A Verification Report of Three Meta‐Analyses in Transcranial Direct‐Current Stimulation—Motor Learning Research

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
Out of the 47 primary effect sizes across the three meta‐analyses verified, 16 could be successfully reproduced or approximated. Thirteen effect sizes, not depicted here, could not be reproduced due to missing information. ABSTRACT With transcranial direct‐current stimulation's (tDCS) popularity both in motor learning research and as a commercial ...
Taym Alsalti, Ian Hussey, Malte Elson, Robert Krause, Steffi Pohl   +4 more
wiley   +1 more source

Simultaneous tDCS-fMRI reveals limited and inconsistent changes in functional connectivity: Insights from a temporal dynamics study. [PDF]

Imaging Neurosci (Camb)
Klooster DCW, Wu GR, de Witte S, Kaalberg K, Kalkhoven B, Mestrom RMC, Baeken C.   +6 more
europepmc   +1 more source