Results 121 to 130 of about 46,637 (281)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Comparison of the Diagnostic Value of Digital Radiography and Temporal Digital Subtraction Radiography in Detection of Dentinal Caries Progression

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2011
Introduction: The development and progress of computerized technologies has revolutionized radiology with digital imaging. The aim of this study is to compare Digital Radiography(DR) and Temporal Digital Subtraction (TDS)in detection of dentinal caries ...
M Shekhi, F Jodeiri
doaj  

Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Anthracyclines are among the most effective chemotherapeutic agents used to treat pediatric malignancies. However, their clinical use is limited by dose‐dependent toxicities, particularly cardiotoxicity and secondary malignancies.
Darleen S. Tu, Aaron K. Olson, Kimberly S. Waggie, Nicolas M. Garcia, Virginia J. Hoglund, Stephanie I. Walter, Jenna R. Rosinski, Harini Sadeeshkumar, Radhika Patel, Erolcan Sayar, Michael C. Haffner, Lisa Maves, Jacques Neefjes, Jay F. Sarthy, Elizabeth R. Lawlor, Shireen S. Ganapathi   +15 more
wiley   +1 more source

Improved Electron Transport Properties in InSb/Ga0.22In0.78Sb Composite Channel HEMT Structures

physica status solidi (a), EarlyView.
The effectiveness of double‐sided Te δ‐doping and engineered buffer structure consisting of GaSb buffer and AlInSb‐graded buffer is investigated in InSb/Ga0.22In0.78 Sb composite channel HEMTs. The degree of threading dislocation suppression is quantitatively analyzed using a pair‐annihilation model.
Tatsuhisa Oba, Tomoki Jinnai, Reo Ebihara, Wataru Nakajima, Ryuto Machida, Issei Watanabe, Yoshimi Yamashita, Shinsuke Hara, Akifumi Kasamatsu, Akira Endoh, Hiroki I. Fujishiro   +10 more
wiley   +1 more source

LIA-QMS method for the quantity analysis of the hydrogen isotopes retention in first-wall components of Globus-M2 tokamak

Nuclear Materials and Energy
The technique based on quadrupole mass spectrometry of the material ejected by laser-induced ablation – LIA-QMS is proposed as a tool to measure H/D/T content in carbon co-deposits in the first wall and divertor regions of tokamak reactors.
O.S. Medvedev, A.G. Razdobarin, E.V. Shubina (Smirnova), M.V. Grishaev, D.I. Elets, L.A. Snigirev, A.S. Kolomiytsev, A.V. Nikolaev   +7 more
doaj   +1 more source

DESIGN, DEVELOPMENT AND PERFORMANCE OF OPTIMUM WATER SOFTENER [PDF]

Earth Sciences Pakistan, 2019
Water is an important factor of life for all living organisms and it is now deteriorated very rapidly due to industrial effluents, municipal and agriculture waste leaching down the groundwater. The percolation of water through the deposits of limestone
Ahmed Sharjeel, Shafiq Anwar, Abdul Nasir,, Haroon Rashid   +3 more
doaj  

Electron Channeling Contrast Imaging for the Characterization of Dislocations in III−V Thin Films on Silicon (001)

physica status solidi (a), EarlyView.
Defect characterization plays a crucial role in semiconductor research, yet the development of fast, cheap, and nondestructive tools remains challenging. This work applies electron channeling contrast imaging (ECCI) to III–V thin films on silicon, examining beam parameters and diffraction conditions.
Laura Monge‐Bartolome, Paula Mouriño Miñambres, Alicia Peiro Codoñer, Miguel Sinusia Lozano, Zhao Yan, Ivan Garcia Vara, Thierry Baron, Qiang Li, Víctor J. Gómez   +8 more
wiley   +1 more source

Suitability Assessment of Cage Fish Farming Location in Reservoirs through Neural Networks-Based Remote Sensing Analysis

Remote Sensing
The present study evaluates the application of different artificial intelligence methods associated with remote sensing data processing for assessing water quality parameters, with a focus on fish cage farming in the reservoirs.
Mahdi Sedighkia, Bithin Datta
doaj   +1 more source

Comparison between design and installed acoustic characteristics of NASA Lewis 9- by 15-foot low-speed wind tunnel acoustic treatment [PDF]

The test section of the NASA Lewis 9- by 15-Foot Low-Speed Wind Tunnel was acoustically treated to allow the measurement of sound under simulated free-field conditions.
Dahl, Milo D., Woodward, Richard P.
core   +1 more source

Dynamics and model representation of two contrasting extreme precipitation events in the Sahel

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Hovmöller diagrams of the two investigated extreme precipitation events in Mali are shown for (i) IMERG observations, and ICOsahedral Nonhydrostatic model (ICON) runs with parameterization of explicit convection (ii) enabled and (iii) disabled. This work highlights that the commonly perceived benefit of using explicit convection in a state‐of‐the‐art ...
Souleymane Sanogo, Marlon Maranan, Andreas H. Fink, Beth J. Woodhams, Peter Knippertz   +4 more
wiley   +1 more source