Results 291 to 300 of about 2,446,131 (337)

In-service Education of Teachers in the Commonwealth

, 1982
Commonwealth Secretariat
openalex   +1 more source

Single‐Cell Transcriptomics Reveals ITGA2‐Mediated Metabolic Reprogramming and Immune Crosstalk in Pediatric Thyroid Carcinogenesis

Advanced Science, EarlyView.
This study unveils ITGA2⁺ tumor cells as key drivers of pediatric thyroid cancer aggressiveness. These cells orchestrate dual oncogenic pathways: GLUT1‐mediated glycolytic reprogramming and M2 macrophage polarization. This metabolic‐immunological crosstalk promotes tumor progression and metastasis.
Zhi‐jun Zhan, Ning Li, Yan Sun, Lu Chen, Jun‐da Yin, Yun‐han Shan, Jia‐xing Zeng, Zhe‐cheng Li, Hai‐long Tan, Neng Tang, Shi Chang, Peng Huang   +11 more
wiley   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

Advanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li, Zhaojun Liu, Linjie Zhu, Gang Wu, Chen Fu, Hongmin Li, Tong He, Ming Shen, Honglin Liu   +8 more
wiley   +1 more source

A Novel Transfer Learning‐Based Hybrid EEG‐fNIRS Brain‐Computer Interface for Intracerebral Hemorrhage Rehabilitation

Advanced Science, EarlyView.
The study has developed the first clinically validated hybrid EEG‐fNIRS brain‐computer interface fusion framework that systematically overcomes cross‐subject generalization barriers through a novel Wasserstein metric‐driven neural template selection mechanism.
Danyang Chen, Jian Shi, Bo Tao, Xingwei Zhao, Zhixian Zhao, Shengjie Li, Yeguang Xu, Tao Ding, Peng Zhang, Qing Ye, Kuiyou Chen, Zhuojin Wu, Yingxin Tang, Wei Jiang, Kai Shu, Li Huang, Zheng You, Ping Zhang, Zhouping Tang   +18 more
wiley   +1 more source

Decoding Handwriting Trajectories from Intracortical Brain Signals for Brain‐to‐Text Communication

Advanced Science, EarlyView.
By developing a novel framework that optimizes both shape and temporal loss during decoder training, the authors successfully reconstruct human‐recognizable handwriting trajectories from intracortical neural signals for both Chinese characters and English letters, effectively resolving the temporal misalignment problem in clinical BCIs, thereby ...
Guangxiang Xu, Zebin Wang, Kedi Xu, Junming Zhu, Jianmin Zhang, Yueming Wang, Yaoyao Hao   +6 more
wiley   +1 more source

Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis‐Associated Tumorigenesis

Advanced Science, EarlyView.
A fecal microbial meta‐analysis reveals that Megasphaera is highly abundant in the Asian population with IBD and CRC. M. elsdenii reshapes colonic immunity by triggering DC cell‐mediated Th1 and Th17 inflammation. M. elsdenii and M. elsdenii‐enriched microbiota exacerbate colonic inflammation and tumorigenesis in AOM/DSS mice.
Xinxin Hou, Zhaozhou Zhang, Wanqing Chen, Jinming Li, Xiangxiang Zhu, Mingjie Li, Xiaoqi Guan, Haidong Guo, Yanlei Ma, Ling Zhao   +9 more
wiley   +1 more source

A Resistive Soft Robotic Exosuit for Dynamic Body Loading in Hypogravity

Advanced Science, EarlyView.
The resistive hypogravity exosuit is a lightweight wearable robotic exosuit that uses pneumatic artificial muscles to restore Earth‐like metabolic and muscular demands during locomotion in low gravity. Tested on healthy subjects in Earth and simulated Moon gravity, the suit restores energy expenditure and muscle activation without altering gait ...
Emanuele Pulvirenti, Richard Suphapol Diteesawat, Gaspare Pavei, Valentina Natalucci, Helmut Hauser, Alberto Minetti, Jonathan Rossiter   +6 more
wiley   +1 more source

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis

Advanced Science, EarlyView.
This study reveals a feedback mechanism regulating copper homeostasis, in which copper directly interacts with TAK1 to activate NF‐κB signaling, while NF‐κB transcriptionally suppresses copper transporter (CTR1) expression. These findings highlight a promising therapeutic strategy for breast cancer by combining NF‐κB inhibitors with copper chelators or
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
wiley   +1 more source

Dynamic Neural Deactivation Bridges Direct and Competitive Inhibition Processes

Advanced Science, EarlyView.
Dynamic neural deactivation bridges traditionally distinct inhibitory mechanisms—direct inhibition and competition‐induced inhibition—revealing a common neural signature across modalities. Multimodal neuroimaging and behavioral experiments demonstrate a temporal dynamic characterized by progressive frontoparietal activation decay and enhanced sensory ...
Zhenhong He, Yifan Du, Ziqi Fu, Youcun Zheng, Nils Muhlert, Barbara Sahakian, Rebecca Elliott   +6 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source