Results 241 to 250 of about 351,613 (301)

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

Atomically Dispersed Cobalt on Ionic Carbon Nitrides for Selective and Efficient Nitrate Electroreduction to Ammonia

Angewandte Chemie, EarlyView.
By exploiting the structural benefits of PHI, we synthesized CoPHI with atomically dispersed cobalt sites at high density. This architecture enables efficient nitrate ion adsorption, promotes water dissociation, and enhances *H generation on the catalyst surface, thereby significantly improving electrochemical nitrate reduction performance.
Nana Gao, Minjuan Guo, Haijian Tong, Guoyu Hou, Jingwen Ba, Xiaoyu Zhang, Ruixin Zhang, Hui Zhang, Xianwei Fu, Leonardo Cancellara, Nadezda V. Tarakina, Yu Zhang, Tianxi Liu, Christian Mark Pelicano, Zhihong Tian   +14 more
wiley   +2 more sources

A State-of-the-Art Review of the Historical Evolution of the Graduate Medical Educator Role. [PDF]

Acad Med
Congdon M, Schultz K, Merkebu J, Varpio L.   +3 more
europepmc   +1 more source

An ultra‐processed food‐based cafeteria diet induces obesity, metabolic dysfunction, and tissue‐specific gene dysregulation in C57BL/6 mice

Animal Models and Experimental Medicine, EarlyView.
This schematic figure illustrates the experimental design and key findings of the study. Forty male C57BL/6 mice were assigned to either a standard diet control group or a cafeteria diet (CAFD) group for 16 weeks. CAFD induces obesity, insulin resistance (HOMA‐IR), hepatic steatosis, and dysregulation of a number of genes in visceral and subcutaneous ...
Guilherme Coutinho Kullmann Duarte, Daisy Crispim, Shiva Cerutti Wittée, Joana Raquel Nunes Lemos, Natalia Emerim Lemos, Mayara Souza de Oliveira, Melissa Daniele Alves, Eloísa Toscan Massignam, Tais Silveira Assmann, Felipe Mateus Pellenz   +9 more
wiley   +1 more source

Strategies for overcoming challenges in implementing simulation in medical education: A qualitative leadership perspective. [PDF]

Medicine (Baltimore)
Delibalta B, Daylan P.
europepmc   +1 more source

Emergent Bilingual and Multilingual Learners in California: Californians Together Passing the Torch to the Next Generation of Advocates (1996 to Present) [PDF]

, 2019
Cheuk, Tina
core  

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

Annals of Neurology, EarlyView.
Objective This study aimed to compare positron emission tomography (PET) and plasma‐based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease. Methods Longitudinal amyloid PET (n = 1,097, mean age ± SD = 72.5 ± 7.38 year, 51.4% male), 18F‐flortaucipir tau‐PET (n = 230, 74.3 ± 7.18 year, 52.2% female), and Fujirebio Lumipulse plasma p‐
Christopher A. Brown, Katheryn A.Q. Cousins, Magdalena Korecka, Emily McGrew, Alice Chen‐Plotkin, John A. Detre, Corey T. McMillan, Edward B. Lee, Sandhitsu R. Das, Dawn Mechanic‐Hamilton, Paul A. Yushkevich, Ilya M. Nasrallah, Leslie M. Shaw, for the Alzheimer's Disease Neuroimaging Initiative, David A. Wolk   +14 more
wiley   +1 more source

Scientometric study of learning circles in medical education: Trends, collaborative networking, and citation dynamics. [PDF]

J Educ Health Promot
Temoche A, Alvitez J, Galarza-Valencia D, Espinoza-Carhuancho F, Cabanillas-Lazo M, Barriga-Yauri G, Mayta-Tovalino F.   +6 more
europepmc   +1 more source

Professional identity formation of clinician-educators through contributions to staff development in neonatology: a qualitative thematic analysis. [PDF]

BMC Med Educ
Shimaoka H, Imafuku R, Saiki T, Suzuki Y.   +3 more
europepmc   +1 more source

Sensory emotional mapping indicators for neurodiverse learners (SEMINEL) framework. [PDF]

MethodsX
A WW, Karthiga RKJ.
europepmc   +1 more source