Results 201 to 210 of about 31,388,696 (397)

Self‐Maintainable Electronic Materials with Skin‐Like Characteristics Enabled by Graphene‐PEDOT:PSS Fillers

open access: yesAdvanced Science, EarlyView.
Graphene‐PEDOT:PSS fillers revolutionize soft electronics by transforming jelly‐like materials into skin‐like systems with self‐healing, heat‐responsiveness, and multiplex sensing capabilities. This novel material exhibits exceptional printability, flexibility, and adhesiveness, enabling seamless integration into bioelectronics and tissue‐cyborganic ...
Morteza Alehosseini   +7 more
wiley   +1 more source

State of the Art of Low‐Frequency Acoustic Modulation: Intensity Enhancement and Directional Control

open access: yesAdvanced Science, EarlyView.
High intensity low‐frequency sound sources hold significant value in many fields. However, their long wavelength, strong penetrability, and tendency to diffract make direction control and intensity enhancement challenging. Acoustic generators and metamaterial‐based acoustic devices still face issues such as low energy efficiency, poor directional ...
Jingsong Xu   +13 more
wiley   +1 more source

Copy Number Gains of VPS72 Drive De Novo Lipogenesis and Hepatocarcinogenesis via ATF3/mTORC1/SREBP1 Axis

open access: yesAdvanced Science, EarlyView.
VPS72 overexpression activates mTORC1 signaling, subsequently promoting lipid synthesis and driving HCC progression. VPS72 modulates the epigenetic landscape of ATF3 promoter, such as H2A.Z acetylation reduction and DNA methylation increase, which results in ATF3 repression and subsequent activation of mTORC1.
Qinglin Zhang   +4 more
wiley   +1 more source

Delivery of Human iPSC‐Derived RPE Cells in Healthy Minipig Retina Results in Interaction Between Photoreceptors and Transplanted Cells

open access: yesAdvanced Science, EarlyView.
Human induced pluripotent stem cell‐derived retinal pigment epithelial (hiPSC‐RPE) cells, cultured on a clinically relevant PDLLA scaffold, are transplanted into immunosuppressed minipigs. The study demonstrates the viability, integration, and preservation of RPE‐specific features without gliosis or neuroinflammation, supporting their potential as a ...
Anna Macečková Brymová   +27 more
wiley   +1 more source

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

open access: yesAdvanced Science, EarlyView.
The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu   +6 more
wiley   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

open access: yesAdvanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li   +13 more
wiley   +1 more source

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