Results 41 to 50 of about 1,628,175 (262)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Team type, team maturity and team effectiveness in specialist palliative home care : an exploratory questionnaire study

, 2019
To meet complex needs in persons and families within specialist palliative care, care team members are expected to work together in performing a comprehensive assessment of patient needs.
Hansson, Johan,, Hagelin, CL, Lundh Hagelin, Carina, Furst, CJ, Klarare, Anna, Fossum, B, Fürst, Carl Johan,, Fossum, Bjöörn,, Hansson, J, Lundh Hagelin, Carina,, Fossum, Bjöörn, Fürst, Carl Johan, Klarare, Anna,, Lund University., Klarare, A, Hansson, Johan   +15 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Replicable Interprofessional Competency Outcomes from High-Volume, Inter-Institutional, Interprofessional Simulation

Pharmacy, 2016
There are significant limitations among the few prior studies that have examined the development and implementation of interprofessional education (IPE) experiences to accommodate a high volume of students from several disciplines and from different ...
Deborah Bambini, Matthew Emery, Margaret de Voest, Lisa Meny, Michael J. Shoemaker   +4 more
doaj   +1 more source

Employer-Sponsored Health Centers Provide Access to Integrated Care via a Hybrid of Virtual and In-Person Visits

Telemedicine Reports, 2021
Background: Since the explosion of telemedicine resulting from the SARS-CoV2 pandemic, employers have been particularly interested in virtual primary care as a novel means of expanding primary care services.
Divya K. Madhusudhan, Sharon A. Watts, Daniel J. Lord, Fiona Ding, David C. Lawrence, Austin Sheldon, James Leonard, Dena M. Bravata   +7 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Re-organisation of oesophago-gastric cancer services in England and Wales: a follow-up assessment of progress and remaining challenges. [PDF]

, 2014
BACKGROUND: This study is an update on an earlier article in 2007 to assess the implementation of the Cancer Plan reform strategy in England and Wales. FINDINGS: A national online survey to upper gastro-intestinal leads at network and trust level.
Hardwick, Richard H, Tom Crosby, David A Cromwell, Georgina Chadwick, Chadwick, Georgina, Crosby, Tom, Cromwell, David A, Richard H Hardwick, Riley, Stuart, Oliver Groene, Stuart Riley, Groene, Oliver, William Allum, Greenaway, Kimberley, Allum, William, Kimberley Greenaway   +15 more
core   +1 more source

Association Between Team-Based Continuity of Care and Risk of Cardiovascular Diseases Among Patients With Diabetes: A Retrospective Cohort Study

, 2022
OBJECTIVE Cardiovascular diseases (CVD) are a long-term sequela of diabetes. Better individualbased continuity of care has been reported to reduce the risk of chronic complications among patients with diabetes. Maintaining a one-to-one patient–physician
Mak, IL, Chan, KS, Cheng, WHG, Ho, MK, Chin, WY, Lam, CLK, Wan, EYF, Yu, EYT   +7 more
core   +1 more source

An early evaluation of team consistency and scope optimization in team-based cancer care

BMC Cancer
Background The British Columbia (BC) government has made significant investments towards the implementation of team-based care (TBC) in its provincial comprehensive cancer control program.
Leah K. Lambert, Farinaz Havaei, Scott M. Beck, Andy Ma, John Larmet, Jagbir Kaur, Nassim Adhami, Dan Le, Ryan Woods   +8 more
doaj   +1 more source

Interprofessional Collaboration in Primary Care: Concept Analysis [PDF]

Journal of Caring Sciences
Introduction: The concept of collaboration in primary care is described using various terms, reflecting differences in context and professional roles. Although interprofessional collaboration is not a new concept in health care, various terms reflect the
M. Agung Akbar, Junaiti Sahar, Yeni Rustina, Etty Rekawati, dan Ratu Ayu Dewi Sartika   +4 more
doaj   +1 more source