Results 171 to 180 of about 219,333 (226)

Managing adolescent eating disorders in primary care: a qualitative study of provider perspectives. [PDF]

J Eat Disord
Drury CR, Downey AE, Vendlinski S, Crest P, Mittal P, Accurso EC.   +5 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Building Social Support and Moral Healing on Nursing Units: Design and Implementation of a Culture Change Intervention. [PDF]

Behav Sci (Basel)
Usset TJ, Godzik C, Harris JI, Wurtz RM, Pyne JM, Edmonds SW, Prunty A, Brown RJL, Bardach SH, Bradley JM, Hubble CL, Oliver BJ, Pepin RL, Currier J, Smith AJ.   +14 more
europepmc   +1 more source

Lactobacillus Salivarius‐Derived Indole‐3‐Acetic Acid Promotes AHR‐PARP1 Axis‐Mediated DNA Repair to Mitigate Intestinal Aging

Advanced Science, EarlyView.
Indole‐3‐acetic acid (IAA) acting as one of the aryl hydrocarbon receptor (AHR) endogenous ligands is identified to be derived from Lactobacillus salivarius via its catalytic enzyme (ALDH) rather than host cells. Lactobacillus salivarius and IAA supplementation effectively mitigate intestinal aging by facilitating AHR‐poly (ADP‐ribose) polymerase 1 ...
Zheng Cao, Cui Zhang, Hehua Lei, Weichuan Lin, Wenkai Yu, Xin Gao, Yanmeng He, Xinzhi Li, Qingwei Xiang, Zhiwen Zhang, Weifei Luo, Andrew D. Patterson, Limin Zhang, Gang Chen   +13 more
wiley   +1 more source

Pandemic mothering: Mothers' experiences of adaptation and resilience during the COVID-19 pandemic. [PDF]

Child Fam Soc Work
Childress S, LaBrenz CA, Findley E.
europepmc   +1 more source

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Toward Sustainable Pesticide Application: Bridging Efficacy and Food Safety

Advanced Science, EarlyView.
A fully bio‐based lignin coacervate system is developed for pesticide delivery, enhancing leaf retention, UV resistance, adhesion, and wetting. The formulation enables pH/laccase‐triggered release for prolonged action, reduces ecological toxicity, and is fully washable, reconciling agricultural efficacy with food and environmental safety.
Xuan Li, Janar Tursen, Wanbin Zhu, Xufeng Yuan, Hongliang Wang   +4 more
wiley   +1 more source

Implementing TeamMAPPS: Formative qualitative findings from the dissemination and implementation study of a new evidence-based team science intervention. [PDF]

J Clin Transl Sci
Molldrem S, Luft H, Farroni JS, Lyons EJ, Wooten K.   +4 more
europepmc   +1 more source