Results 211 to 220 of about 1,517,602 (292)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Proteomic Analysis of Tear Film in Dogs and Cats: Emerging Biomarkers of Cognitive Dysfunction and Neurodegenerative Disorders. [PDF]

Animals (Basel)
Winiarczyk D, Winiarczyk M.
europepmc   +1 more source

The Effect of Ligand Reactivity and Carrier Mechanics on Thiol‐Mediated Cellular Uptake for miRNA Nano‐Drugs

Advanced Science, EarlyView.
The effect of ligand reactivity and carrier mechanics on thiol‐mediated uptake was investigated at the single‐molecule/particle level. The interaction kinetics of LA and AspA with membrane thiols were quantified; AspA is more efficient due to the higher binding affinity, greater binding stability, and more double‐disulfide binding, as well as greater ...
Zhuang Zhang, Hui Wang, Hao Zhang, Zhenkuan Cao, Zehui Liu, Siying Li, Hongda Wang, Yuping Shan   +7 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

Dry eye disease in axial spondyloarthritis: heterogeneous ocular surface dysfunction involving tear film instability and tear production from the AIDA network registry. [PDF]

Front Med (Lausanne)
Caggiano V, Vitale A, Sbalchiero J, Tufan A, Guaracha-Basañez GA, Kawakami-Campos PA, Hinojosa-Azaola A, Duran R, Kucuk H, Ragab G, Ruscitti P, Lopalco G, Karamanakos A, Fotis L, Ghanema M, Cipriani P, Morrone M, Dimouli A, Kourtesi K, Tharwat S, Moshrif A, Sota J, Mayo-Juanatey A, Boyarchuk O, Edrees A, Barone P, Carubbi F, Chimenti MS, Conforti A, Thabet M, Opris-Belinski D, Erten Ş, Hegazy MT, Mazzei MA, Piscitello C, Frediani B, Balistreri A, Cifuentes-González C, de-la-Torre A, Cantarini L, Fabiani C.   +40 more
europepmc   +1 more source

Electronics‐Free Visual Monitoring of Dry Eye Disease‐Related Tear Biomarkers Using Smart Scleral Lenses

Advanced Science, EarlyView.
An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang, Sang Mok Park, Dawn Meyer, Seul Ah Lee, Yumin Dai, Tianhao Yu, Taewoong Park, Feiyang Li, Jason Gerard Jedlicka, Tristan Michael Long, Oluwabunmi T. Oladele, Gillian C. Shaw, Shin Ae Park, Pete S. Kollbaum, Young L. Kim, Chi Hwan Lee   +15 more
wiley   +1 more source

Serum 25-hydroxyvitamin D and tear-film stability in dry eye disease: A case-control correlation study. [PDF]

Bioinformation
Singh A, Kushwaha P, Sharma PK.
europepmc   +1 more source

MOF‐Derived Cu‐TiO2/Alginate Micromotors for Buoyancy‐Regulated 3D Motion

Advanced Science, EarlyView.
In this work, cyanobacteria‐inspired sodium alginate (SA)/Cu‐TiO2/Fe3O4 hydrogel micromotors generate and encapsulate O2 microvesicles upon light irradiation, enabling buoyancy‐mediated Z‐axis upward migration and surface enrichment at the light‐exposed water‐air surface.
Wei Zou, Qing Wu, Jiawei Lin, Kunchen Li, Yulong Ying, Josep Puigmartí‐Luis, Salvador Pané, Sheng Wang   +7 more
wiley   +1 more source

Freestanding Hierarchical‐Porous BCZT Thin Films Enable Efficient Ultrasonic Energy Harvesting in Soft Tissue

Advanced Science, EarlyView.
Freestanding hierarchical‐porous BCZT thin films integrate a compliant porous surface with a dense piezoceramic backbone to balance mechanical reliability, voltage sensitivity, and acoustic coupling. The films enable stable wearable pulse‐wave monitoring and enhanced tissue‐coupled ultrasonic energy harvesting, offering a promising route toward soft ...
Zifan Li, Shengwei Gao, Wang Hong, Yuxin Chen, Yiyang Gu, Xu Wang, Chen Tang, Ying Hong, Xuemu Li, Xiaodong Yan, Yi Zheng, Yiming Liu, Junchen Liao, Biao Wang, Shiyuan Liu   +14 more
wiley   +1 more source

Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model. [PDF]

Invest Ophthalmol Vis Sci
Willems M, Girard M, Feret N, Touchet D, Vialaret J, Kindermans J, Fichter L, Hirtz C, Bremond-Gignac D, Daien V, Delettre C, Pequignot M, Michon F.   +12 more
europepmc   +1 more source