Results 91 to 100 of about 98,109 (298)

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Statistical analysis plan for the 5-year and 10-year follow-up assessments of the FIDELITY trial

Trials, 2020
Background The research objectives of the 5-year and 10-year assessments in the Finnish degenerative meniscal lesion study (FIDELITY) are twofold: (1) to assess the long-term efficacy of arthroscopic partial meniscectomy (APM) in adults (age 35 to 65 ...
Raine Sihvonen, Roope Kalske, Martin Englund, Aleksandra Turkiewicz, Pirjo Toivonen, Simo Taimela, Teppo L. N. Järvinen, for the Finnish Degenerative Meniscal Lesion Study (FIDELITY) Investigators   +7 more
doaj   +1 more source

High Rate of Recurrent Meniscus Tear and Lateral Compartment Osteoarthritis in Patients Treated for Symptomatic Lateral Discoid Meniscus: A Long-Term Population-Based Study

Orthopaedic Journal of Sports Medicine, 2019
Objectives: Little is known about the natural history and long-term outcome of a surgically treated symptomatic lateral discoid meniscus. The goals of this study were to describe the rate and factors associated with recurrent lateral meniscus tears and ...
Orlando Sabbag MD, Mario Hevesi MD, Thomas L. Sanders MD, Christopher L. Camp MD, Diane L. Dahm MD, Bruce A. Levy MD, Michael J. Stuart MD, Aaron John Krych MD   +7 more
doaj   +1 more source

Combined autologous chondrocyte implantation and meniscus reconstruction for large chondral defect in the lateral compartment due to discoid lateral meniscus tear: A case report

, 2019
Discoid lateral meniscus tear leads to large chondral defect in the lateral compartment of the knee joint. There are few effective treatments for large chondral defect in both the tibial and femoral sides with severe degenerative lateral meniscus.
Shin Yamada, Hiroshi Ohuchi, Shuzo Takazawa, Yuki Kato, Soichi Hattori   +4 more
core   +1 more source

Early Synovial Regulatory T Cell Engagement in Posttraumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) develops despite restoration of joint biomechanics, suggesting that early postinjury biologic processes within the synovium shape disease trajectories. We investigated whether synovial Treg cells are engaged during the early phase following joint injury and whether experimental enrichment of this ...
Xueyou Zhang, Mingde Cao, Jianting Li, Bruma Sai‐Chuen Fu, Michael Tim‐Yun Ong, Patrick Shu‐Hang Yung   +5 more
wiley   +1 more source

Meniscus tears

, 2023
The meniscus is an important component of the knee joint. His function is to helps prevent articular cartilage degeneration and the onset of osteoarthritis. It serves a unique role in load bearing, load transmission, shock absorption, lubrication, and nutrition of articular cartilage.
openaire   +1 more source

Outside-in Repair Technique for a Complete Radial Tear of the Lateral Meniscus

Arthroscopy Techniques, 2018
The lateral meniscus is vital in dissipating the force in the lateral compartment of the knee. A complete radial tear of the meniscus can lead to extrusion, rendering it nonfunctional and resulting in deleterious arthritic changes to the lateral ...
Samuel R.H. Steiner, M.D., Scott M. Feeley, B.S., Jeffrey R. Ruland, B.A., David R. Diduch, M.D.   +3 more
doaj   +1 more source

Prolonged increase in tear meniscus height by 3% diquafosol ophthalmic solution in eyes with contact lenses

, 2015
Yukiko Nagahara,1 Shizuka Koh,1 Kohji Nishida,1 Hitoshi Watanabe1,2 1Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, 2Kansai Rosai Hospital, Amagasaki, Hyogo, Japan Purpose: This study aimed to evaluate the
Nishida K, Koh S, Nagahara Y, Watanabe H
core  

Differences in the Association Between Medial Meniscus Tears and Focal Cartilage Lesions According to Tear Configuration

Orthopaedic Journal of Sports Medicine
Background: There are no statistical analyses on the association between the configuration of medial meniscus tears and the location of focal cartilage lesions.
Taehyeon Jeon MD, Jong-Min Kim PhD, MD, Bum-Sik Lee PhD, MD, Seong-Il Bin PhD, MD, Jongjin Lee MD, Kinam Bae MD, Donghyok Kim MD   +6 more
doaj   +1 more source

Arthroscopic Repair of Double Radial Tears of the Lateral Meniscus

Arthroscopy Techniques, 2019
Double radial tears of the lateral meniscus are rare injuries that typically occur in the setting of an acute anterior cruciate ligament rupture. Full-thickness radial tears of the meniscus body and root render the meniscus nonfunctional from a loss of ...
Nels D. Leafblad, M.D., Devin P. Leland, B.S., Christopher L. Camp, M.D., Michael J. Stuart, M.D., Aaron J. Krych, M.D.   +4 more
doaj   +1 more source