Results 201 to 210 of about 255,988 (347)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

New Insights on Fatigue Crack Growth of Reinforced Natural Rubber. [PDF]

Polymers (Basel)
Kyei-Manu WA, Tunnicliffe LB, Herd CR, Akutagawa K, Busfield JJC.   +4 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Clinical effect of percutaneous endoscopic visual trephine decompression combined with pedicle screw fixation in the treatment of lumbar vertebral burst fracture with secondary spinal canal stenosis. [PDF]

Acta Neurochir (Wien)
Li K, Jiang B, Han Y.
europepmc   +1 more source

Crocodile Tears [PDF]

BMJ, 1963
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Energetic spectra from semi-implicit particle-in-cell simulations of magnetic reconnection. [PDF]

Sci Rep
Schoeffler KM, Bacchini F, Kormann K, Eichmann B, Innocenti ME.   +4 more
europepmc   +1 more source

Effect of Zn addition on hot tearing behaviour of Mg–0.5Ca–xZn alloys

, 2015
Jiangfeng Song, Zhi Wang, Yuanding Huang, A. Srinivasan, F. Beckmann, K. Kainer, N. Hort   +6 more
semanticscholar   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Reproxalap - A Novel Treatment Option for Allergic Conjunctivitis - A Comprehensive Narrative Review. [PDF]

Health Sci Rep
Mughal S, Awan RE, Abbas H, Sania Z, Habib A, Sakina SK, Mahmud A, Eljack MMF.   +7 more
europepmc   +1 more source